Detailed information of TA system TA240417

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1926465..1927241
• Replicon: chromosome
• Accession: NZ_CP094787
• Organism: Staphylococcus aureus strain IVB6168

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: MUA13_RS09295
• Protein ID: WP_000031108.1
• Coordinates: 1926465..1926617 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: MUA13_RS09300
• Protein ID: WP_001251226.1
• Coordinates: 1926642..1927241 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA13_RS09280 (MUA13_09270)	1922426..1923247	+	822	WP_089518425.1	RluA family pseudouridine synthase	-
MUA13_RS09285 (MUA13_09275)	1923710..1925095	-	1386	WP_000116229.1	class II fumarate hydratase	-
MUA13_RS09290 (MUA13_09280)	1925291..1925686	-	396	WP_000901023.1	hypothetical protein	-
MUA13_RS09295 (MUA13_09285)	1926465..1926617	-	153	WP_000031108.1	SAS053 family protein	Toxin
MUA13_RS09300 (MUA13_09290)	1926642..1927241	-	600	WP_001251226.1	glucosamine-6-phosphate isomerase	Antitoxin
MUA13_RS09305 (MUA13_09295)	1927401..1927871	-	471	WP_000181398.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
MUA13_RS09310 (MUA13_09300)	1927876..1929003	-	1128	WP_252570299.1	tRNA epoxyqueuosine(34) reductase QueG	-
MUA13_RS09315 (MUA13_09305)	1929154..1929876	-	723	WP_262522383.1	amino acid ABC transporter ATP-binding protein	-
MUA13_RS09320 (MUA13_09310)	1929869..1931326	-	1458	WP_252570295.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T240417 WP_000031108.1 NZ_CP094787:c1926617-1926465 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T240417 NZ_LS999206:c3043013-3042660 [Enterobacter hormaechei]
GTGTGGGCGATTAAAACTACGGACAGGTTTGACGACTGGTTCACCTCATTAAACGATAGCGAGAGAGCCAGCGTACTGGC
CGCGCTACTTGTTTTGCGGGAGAGGGGACCGGGTCTGTCCAGACCGTATGCCGATACGCTGAAAGGCTCCCGCCACAGCA
ACATGAAAGAGTTGCGTATCCAGAGTAAGGGTGATCCGCTGAGGGCATTTTTCGCTTTCGATCCGAACCGTACGGGTATT
GTACTGTGTGCGGGCAATAAGGTCGGTAATGAAAGGCGATTTTACGATGAGATGCTCCTCGTTGCGGATCGGGAATACAC
TCGCTGGCTGAACACATTAAAAGAGAGGAATTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22373.50 Da
• Isoelectric Point: 5.1445

>AT240417 WP_001251226.1 NZ_CP094787:c1927241-1926642 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAATGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT240417 NZ_LS999206:c3042655-3042353 [Enterobacter hormaechei]
ATGGGCAGAACCCTGGAGCAGCTTATTGCAGATGAAAAACCTGAGGTTGTTGCCAGCGCACAGGCAATGGCAACGGATAT
TTTGCTCAATATCCATCTGGCCGAGTTACGTGAAAAAGTGCAAAAAACGCAGGTAGATATGGCCAGGGCGTTGGGTATTA
AACAACCTACTGTCGCCGTCATGGAAAAGGCAGGACGCGATATTAAGCTTTCTTCTTTGAAACGCTACGTTGAGGCCGCC
GGAGGGAAGCTACGGCTGGATGTAGAACTACCCGATGGTTCTCATTACGAGTTTGTGTTGTAA

Structures

Toxin

• AlphaFold DB: X5E2E6