Detailed information of TA system TA240416

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 879744..880221
• Replicon: chromosome
• Accession: NZ_CP094787
• Organism: Staphylococcus aureus strain IVB6168

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: MUA13_RS04255
• Protein ID: WP_000052076.1
• Coordinates: 879744..879932 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: MUA13_RS04260
• Protein ID: WP_001059690.1
• Coordinates: 879961..880221 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA13_RS04225 (MUA13_04220)	875747..876256	+	510	WP_252570470.1	hypothetical protein	-
MUA13_RS04230 (MUA13_04225)	876597..877283	+	687	WP_252570468.1	thermonuclease family protein	-
MUA13_RS04235 (MUA13_04230)	877640..877840	+	201	WP_001059082.1	cold-shock protein	-
MUA13_RS04240 (MUA13_04235)	878335..878553	-	219	WP_000005886.1	hypothetical protein	-
MUA13_RS04245 (MUA13_04240)	878615..878899	-	285	WP_001004395.1	hypothetical protein	-
MUA13_RS04250 (MUA13_04245)	878987..879556	-	570	WP_001106654.1	lipoprotein N-acylation protein LnsA	-
MUA13_RS04255 (MUA13_04250)	879744..879932	-	189	WP_000052076.1	hypothetical protein	Toxin
MUA13_RS04260 (MUA13_04255)	879961..880221	-	261	WP_001059690.1	hypothetical protein	Antitoxin
MUA13_RS04265 (MUA13_04260)	880562..880765	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
MUA13_RS04270 (MUA13_04265)	880762..880998	-	237	WP_000368687.1	hypothetical protein	-
MUA13_RS04275 (MUA13_04270)	881223..881804	+	582	WP_001140696.1	histidine phosphatase family protein	-
MUA13_RS04280 (MUA13_04275)	881877..882494	-	618	WP_000255557.1	LysE/ArgO family amino acid transporter	-
MUA13_RS04285 (MUA13_04280)	882649..883143	-	495	WP_000569884.1	GNAT family N-acetyltransferase	-
MUA13_RS04290 (MUA13_04285)	883542..883964	-	423	WP_000974460.1	organic hydroperoxide resistance protein	-
MUA13_RS04295 (MUA13_04290)	884112..884828	+	717	WP_000150020.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Antitoxin

• Toxin YoeB (5-84)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T240416 WP_000052076.1 NZ_CP094787:c879932-879744 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T240416 NZ_LS999206:c2975705-2975454 [Enterobacter hormaechei]
ATGCGCACTATCAGCTATACCGAAGCCCGGCAGAACCTGTCGGCCACCATGGTGCAGACCGTCGAGGATCGCGTGCCTAC
CCTCATTACCCGCCAGAACGGCGAGGCGTGCGTGCTGATGTCGCTGGAGGAGTACAACGCGCTGGAGGAAACGGCTTACC
TGCTGCGCTCGCCGGCCAACGCGCGCCGCCTGATGGATTCGATTGACAGCCTCAAGCGTGGCCAGGGTGTCGAGCGGGAT
ATCGCCGAGTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT240416 WP_001059690.1 NZ_CP094787:c880221-879961 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT240416 NZ_LS999206:c2975457-2975203 [Enterobacter hormaechei]
GTGAAGCTGATCTGGTCTGAGCAAGCCTGGGACGATTATCTGTACTGGCAAGAGGCGGATAAGCGTATGGTCAAGAAGCT
CAACGAGCTGATCAAGGAGACCCGCCGCACCCCTTTCGAGGGCAAGGGCAAGCCGGAGCCGCTTCGCCACAACCTGGCGG
GCTTCTGGTCGAGGCGGATCACCGCCGAGCACCGGTTTGTGTATTCGGTGACGGACGAGGCGCTGCTGATTGCCGCCTGC
CGTTATCACTATTGA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56