Detailed information of TA system TA024041

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1558907..1559547
• Replicon: chromosome
• Accession: NC_012943
• Organism: Mycobacterium tuberculosis KZN 1435

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TQ08
• Locus tag: TBMG_RS07485
• Protein ID: WP_003412970.1
• Coordinates: 1559128..1559547 (+)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TQ09
• Locus tag: TBMG_RS07480
• Protein ID: WP_003412975.1
• Coordinates: 1558907..1559131 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TBMG_RS07460	1554524..1555087	+	564	WP_003412989.1	elongation factor P	-
TBMG_RS07465	1555090..1555560	+	471	WP_003899364.1	transcription antitermination factor NusB	-
TBMG_RS07470	1555560..1555961	+	402	WP_003412981.1	hypothetical protein	-
TBMG_RS07475	1556033..1558876	+	2844	WP_003899363.1	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
TBMG_RS07480	1558907..1559131	+	225	WP_003412975.1	antitoxin VapB39	Antitoxin
TBMG_RS07485	1559128..1559547	+	420	WP_003412970.1	type II toxin-antitoxin system VapC family toxin	Toxin
TBMG_RS07490	1559548..1560498	-	951	WP_003911916.1	Lsr2 family protein	-
TBMG_RS22250	1560557..1560802	+	246	WP_071854223.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
TBMG_RS07495	1561143..1562063	+	921	WP_003412965.1	restriction endonuclease	-
TBMG_RS07500	1562098..1562499	-	402	WP_003412963.1	PIN domain-containing protein	-
TBMG_RS07505	1562496..1562723	-	228	WP_003412960.1	type II toxin-antitoxin system VapB family antitoxin	-
TBMG_RS07510	1563240..1563962	+	723	WP_003412957.1	DUF1906 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 14732.70 Da
• Isoelectric Point: 6.7519

>T24041 WP_003412970.1 NC_012943:1559128-1559547 [Mycobacterium tuberculosis KZN 1435]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL

Nucleotide

• Length: 420 bp

>T24041 NC_012943:1559128-1559547 [Mycobacterium tuberculosis KZN 1435]
GTGACGGCACTGCTCGATGTCAATGTGCTGATCGCGCTGGGCTGGCCGAATCACGTTCACCATGCGGCCGCGCAGCGATG
GTTCACGCAGTTCTCCTCGAATGGGTGGGCCACCACGCCGATCACCGAGGCAGGGTATGTCCGAATTTCAAGCAATCGCA
GTGTGATGCAGGTGTCGACCACGCCGGCTATCGCGATCGCTCAGTTGGCGGCGATGACTTCTCTTGCCGGGCACACGTTT
TGGCCTGACGATGTGCCACTGATCGTTGGGAGCGCCGGCGATCGCGATGCGGTGTCCAACCACCGTCGGGTCACCGACTG
CCATCTCATCGCCTTGGCCGCGCGCTACGGGGGCCGGTTGGTCACATTCGATGCCGCACTGGCCGATTCAGCATCCGCAG
GCCTCGTCGAGGTGTTGTAG

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 7993.94 Da
• Isoelectric Point: 4.0057

>AT24041 WP_003412975.1 NC_012943:1558907-1559131 [Mycobacterium tuberculosis KZN 1435]
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV

Nucleotide

• Length: 225 bp

>AT24041 NC_012943:1558907-1559131 [Mycobacterium tuberculosis KZN 1435]
ATGCGCACCACGTTGCAGATTGATGATGATGTTCTAGAAGATGCTCGTAGCATCGCGCGGTCGGAGGGCAAGTCAGTCGG
CGCGGTAATTTCTGAGTTGGCGCGTAGGTCGCTCCGTCCGGTTGGGATTGTCGAGGTTGACGGATTTCCGGTTTTTGATG
TTCCGCCGGATGCGCCGACGGTGACTTCCGAGGATGTCGTCCGCGCGCTCGAGGACGACGTGTGA

Structures

Toxin

• AlphaFold DB: G0TQ08

Antitoxin

• AlphaFold DB: G0TQ09