Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2255526..2256040 Replicon chromosome
Accession NZ_CP094785
Organism Staphylococcus aureus strain IVB6169

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag MUA79_RS11395 Protein ID WP_000581791.1
Coordinates 2255526..2255735 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag MUA79_RS11400 Protein ID WP_000138934.1
Coordinates 2255747..2256040 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA79_RS11375 (MUA79_11360) 2251415..2252485 - 1071 WP_000159638.1 D-alanine--D-alanine ligase -
MUA79_RS11380 (MUA79_11365) 2252803..2254005 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
MUA79_RS11385 (MUA79_11370) 2254166..2254849 - 684 Protein_2204 transposase -
MUA79_RS11390 (MUA79_11375) 2255261..2255398 - 138 WP_000828354.1 Lmo0850 family protein -
MUA79_RS11395 (MUA79_11380) 2255526..2255735 - 210 WP_000581791.1 heavy metal-associated domain-containing protein Toxin
MUA79_RS11400 (MUA79_11385) 2255747..2256040 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA79_RS11405 (MUA79_11390) 2256206..2257690 + 1485 WP_000571560.1 cardiolipin synthase -
MUA79_RS11410 (MUA79_11395) 2257718..2258365 + 648 WP_001187612.1 HD domain-containing protein -
MUA79_RS11415 (MUA79_11400) 2259078..2259950 - 873 WP_000725802.1 membrane protein insertase YidC -
MUA79_RS11420 (MUA79_11405) 2260036..2260677 - 642 WP_045179393.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T240408 WP_000581791.1 NZ_CP094785:c2255735-2255526 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T240408 NZ_LS999206:c299054-298752 [Enterobacter hormaechei]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAATTTAAAGGACAGGCGGGCAAAGACGATTATCGC
TTCCCGCCTCTTTAGGCTGGCAAATGGCTTAGCGGGCGACATTAGACCCGTGGGGGAAGGTATCAGTGAACTGAGGATCC
ACTTTGGCCCGGGCTACAGAGTCTATTTTAAGGACCAGGGCAATTGCATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT240408 WP_000138934.1 NZ_CP094785:c2256040-2255747 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT240408 NZ_LS999206:c298745-298458 [Enterobacter hormaechei]
ATGCATAAATTAACACCCTACGATCCAGCCAACGCACTGGTGGATGACGAGGAAATCGCTGTGTTTATGGCTGATGCATT
AGAGACGGGTGACTCAGCGTACATTGCTGAAGCGCTGGGCGTCATCGCCCGAGCGAAAGGGATGTCGACCATTTCCCAGC
AAACGGGCCTGTCACGAGAACAACTGTATCGATCATTCAGTGATAAGGGGAACCCAACGCTCAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGCCTTGGGTTAACAATCAAACCCTCTGGGGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References