Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC(toxin) |
| Location | 1544951..1545660 | Replicon | chromosome |
| Accession | NC_012943 | ||
| Organism | Mycobacterium tuberculosis KZN 1435 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | G0TQ26 |
| Locus tag | TBMG_RS07400 | Protein ID | WP_003413164.1 |
| Coordinates | 1545247..1545660 (-) | Length | 138 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | P95006 |
| Locus tag | TBMG_RS07395 | Protein ID | WP_003413167.1 |
| Coordinates | 1544951..1545208 (-) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| TBMG_RS07355 | 1540044..1540556 | + | 513 | WP_003413197.1 | Holliday junction resolvase RuvX | - |
| TBMG_RS07360 | 1540549..1541802 | + | 1254 | WP_003413196.1 | endolytic transglycosylase MltG | - |
| TBMG_RS07365 | 1541799..1542608 | + | 810 | WP_003413193.1 | shikimate dehydrogenase | - |
| TBMG_RS07370 | 1542620..1543039 | + | 420 | WP_003413190.1 | A24 family peptidase | - |
| TBMG_RS07375 | 1543450..1543695 | + | 246 | WP_003413183.1 | type II toxin-antitoxin system antitoxin VapB20 | - |
| TBMG_RS07380 | 1543692..1544087 | + | 396 | WP_003413180.1 | type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 | - |
| TBMG_RS07385 | 1544187..1544561 | + | 375 | WP_003413177.1 | hypothetical protein | - |
| TBMG_RS07390 | 1544577..1544954 | - | 378 | WP_003413174.1 | type II toxin-antitoxin system VapC family toxin | - |
| TBMG_RS07395 | 1544951..1545208 | - | 258 | WP_003413167.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
| TBMG_RS07400 | 1545247..1545660 | - | 414 | WP_003413164.1 | PIN domain nuclease | Toxin |
| TBMG_RS07405 | 1545753..1546031 | - | 279 | WP_012775752.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| TBMG_RS07410 | 1546028..1546690 | - | 663 | WP_003900848.1 | hypothetical protein | - |
| TBMG_RS07415 | 1546687..1547346 | - | 660 | WP_003900846.1 | LppA family lipoprotein | - |
| TBMG_RS07420 | 1547473..1548684 | - | 1212 | WP_003900845.1 | alpha/beta hydrolase family protein | - |
| TBMG_RS07425 | 1548980..1549294 | - | 315 | WP_009937839.1 | hypothetical protein | - |
| TBMG_RS07430 | 1549402..1550607 | + | 1206 | WP_003413027.1 | chorismate synthase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 138 a.a. Molecular weight: 15045.00 Da Isoelectric Point: 5.4673
>T24040 WP_003413164.1 NC_012943:c1545660-1545247 [Mycobacterium tuberculosis KZN 1435]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL
Download Length: 414 bp
>T24040 NC_012943:c1545660-1545247 [Mycobacterium tuberculosis KZN 1435]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9453.63 Da Isoelectric Point: 10.6555
>AT24040 WP_003413167.1 NC_012943:c1545208-1544951 [Mycobacterium tuberculosis KZN 1435]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA
Download Length: 258 bp
>AT24040 NC_012943:c1545208-1544951 [Mycobacterium tuberculosis KZN 1435]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TQ26 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829C9W5 |