Detailed information of TA system TA240399

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 934388..934865
• Replicon: chromosome
• Accession: NZ_CP094785
• Organism: Staphylococcus aureus strain IVB6169

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: MUA79_RS04615
• Protein ID: WP_000052076.1
• Coordinates: 934388..934576 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: MUA79_RS04620
• Protein ID: WP_001059690.1
• Coordinates: 934605..934865 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA79_RS04585 (MUA79_04575)	930341..930898	+	558	WP_045178710.1	hypothetical protein	-
MUA79_RS04590 (MUA79_04580)	931239..931925	+	687	WP_001574556.1	thermonuclease family protein	-
MUA79_RS04595 (MUA79_04585)	932282..932482	+	201	WP_001059082.1	cold-shock protein	-
MUA79_RS04600 (MUA79_04590)	932979..933197	-	219	WP_000005879.1	hypothetical protein	-
MUA79_RS04605 (MUA79_04595)	933259..933543	-	285	WP_001004401.1	hypothetical protein	-
MUA79_RS04610 (MUA79_04600)	933631..934200	-	570	WP_001106663.1	lipoprotein N-acylation protein LnsA	-
MUA79_RS04615 (MUA79_04605)	934388..934576	-	189	WP_000052076.1	hypothetical protein	Toxin
MUA79_RS04620 (MUA79_04610)	934605..934865	-	261	WP_001059690.1	hypothetical protein	Antitoxin
MUA79_RS04625 (MUA79_04615)	935206..935409	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
MUA79_RS04630 (MUA79_04620)	935406..935642	-	237	WP_000368687.1	hypothetical protein	-
MUA79_RS04635 (MUA79_04625)	935866..936447	+	582	WP_001140696.1	histidine phosphatase family protein	-
MUA79_RS04640 (MUA79_04630)	936520..937137	-	618	WP_000255548.1	LysE/ArgO family amino acid transporter	-
MUA79_RS04645 (MUA79_04635)	937293..937787	-	495	WP_000569884.1	GNAT family N-acetyltransferase	-
MUA79_RS04650 (MUA79_04640)	938186..938608	-	423	WP_000974455.1	organic hydroperoxide resistance protein	-
MUA79_RS04655 (MUA79_04645)	938756..939472	+	717	WP_000150025.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	tsst-1 / vWbp	902228..940094	37866

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-100)

Antitoxin

• Post-segregation antitoxin CcdA (2-72)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T240399 WP_000052076.1 NZ_CP094785:c934576-934388 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T240399 NZ_LS998786:79071-79376 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCTGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGTTGTCAGATAAGGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAGGAAGTG
GCTGATCTCAGCCACCGAGAAAATGACATCAAAAATGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT240399 WP_001059690.1 NZ_CP094785:c934865-934605 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT240399 NZ_LS998786:78851-79069 [Escherichia coli]
ATGAAGCAGCGCATTACAGTCACCGTCGACAGTGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGGCT
GGTAAGCACCACCCTGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCAGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGACGAGAACAGGGACTGGTGA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56