240397

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 449012..449550 Replicon chromosome
Accession NZ_CP094785
Organism Staphylococcus aureus strain IVB6169

Toxin (Protein)


Gene name TscT Uniprot ID -
Locus tag MUA79_RS02145 Protein ID WP_045178601.1
Coordinates 449224..449550 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID -
Locus tag MUA79_RS02140 Protein ID WP_045178599.1
Coordinates 449012..449221 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA79_RS02105 (MUA79_02105) 445221..446141 - 921 Protein_418 tyrosine-type recombinase/integrase -
MUA79_RS02110 (MUA79_02110) 446420..447049 - 630 WP_231858805.1 XRE family transcriptional regulator -
MUA79_RS02115 (MUA79_02115) 447072..447596 - 525 Protein_420 SAP domain protein -
MUA79_RS02120 (MUA79_02120) 447623..448195 - 573 WP_001186980.1 helix-turn-helix transcriptional regulator -
MUA79_RS02125 (MUA79_02125) 448367..448588 + 222 WP_000560872.1 helix-turn-helix transcriptional regulator -
MUA79_RS02130 (MUA79_02130) 448589..448861 + 273 WP_000124597.1 helix-turn-helix domain-containing protein -
MUA79_RS02135 (MUA79_02135) 448873..449019 + 147 WP_000784893.1 hypothetical protein -
MUA79_RS02140 (MUA79_02140) 449012..449221 + 210 WP_045178599.1 hypothetical protein Antitoxin
MUA79_RS02145 (MUA79_02145) 449224..449550 + 327 WP_045178601.1 DUF1474 family protein Toxin
MUA79_RS02150 (MUA79_02150) 449615..450484 + 870 WP_045178602.1 primase alpha helix C-terminal domain-containing protein -
MUA79_RS02155 (MUA79_02155) 450498..452207 + 1710 Protein_428 DUF927 domain-containing protein -
MUA79_RS02160 (MUA79_02160) 452518..452898 + 381 WP_000356932.1 hypothetical protein -
MUA79_RS02165 (MUA79_02165) 452895..453536 + 642 WP_045178603.1 pathogenicity island protein -
MUA79_RS02170 (MUA79_02170) 453884..454225 + 342 WP_001190600.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 437267..464105 26838


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 13093.44 Da        Isoelectric Point: 4.6496

>T240397 WP_045178601.1 NZ_CP094785:449224-449550 [Staphylococcus aureus]
MNLEINDLFSDLKLLKDRFEDLKDSHGWHFEELYPHEPNHNLNKDELIREGFSYHERRIHNNQMFDLFHLYIEQFDKIIE
KFHEIEKASSENFGEESDDAKNSIKVAE

Download         Length: 327 bp

>T240397 NZ_LS998786:21650-21856 [Escherichia coli]
ATGAAGTACCTTAACACTACTGATTGTAGCCTCTTCCTTGCAGGGAGGTCAAAGTTTATGACGAAATATGCCCTTATCGG
GTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTTATGTGAACTGAATATTCACAGGG
GAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8220.25 Da        Isoelectric Point: 4.3718

>AT240397 WP_045178599.1 NZ_CP094785:449012-449221 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELILKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT240397 NZ_LS998786:c21663-21602 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References