240393

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2108049..2108563 Replicon chromosome
Accession NZ_CP094783
Organism Staphylococcus aureus strain IVB6170

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag MUA30_RS10535 Protein ID WP_000581792.1
Coordinates 2108049..2108258 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag MUA30_RS10540 Protein ID WP_000138932.1
Coordinates 2108270..2108563 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA30_RS10515 (2103557) 2103557..2104915 - 1359 WP_262610211.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
MUA30_RS10520 (2104930) 2104930..2106000 - 1071 WP_262610212.1 D-alanine--D-alanine ligase -
MUA30_RS10525 (2106318) 2106318..2107520 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
MUA30_RS10530 (2107784) 2107784..2107921 - 138 WP_000828354.1 Lmo0850 family protein -
MUA30_RS10535 (2108049) 2108049..2108258 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
MUA30_RS10540 (2108270) 2108270..2108563 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA30_RS10545 (2108729) 2108729..2110213 + 1485 WP_000571549.1 cardiolipin synthase -
MUA30_RS10550 (2110241) 2110241..2110888 + 648 WP_001187634.1 HD domain-containing protein -
MUA30_RS10555 (2111501) 2111501..2112373 - 873 WP_000725802.1 membrane protein insertase YidC -
MUA30_RS10560 (2112459) 2112459..2113100 - 642 WP_262610213.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T240393 WP_000581792.1 NZ_CP094783:c2108258-2108049 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T240393 NZ_LS998785:3494027-3494245 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTTTGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT240393 WP_000138932.1 NZ_CP094783:c2108563-2108270 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT240393 NZ_LS998785:3493627-3494001 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References