Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2088309..2088838 Replicon chromosome
Accession NZ_CP094783
Organism Staphylococcus aureus strain IVB6170

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MUA30_RS10445 Protein ID WP_000621175.1
Coordinates 2088309..2088671 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag MUA30_RS10450 Protein ID WP_000948331.1
Coordinates 2088668..2088838 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA30_RS10425 (2085288) 2085288..2086058 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
MUA30_RS10430 (2086033) 2086033..2086512 - 480 WP_001190829.1 anti-sigma B factor RsbW -
MUA30_RS10435 (2086514) 2086514..2086840 - 327 WP_262610201.1 anti-sigma factor antagonist -
MUA30_RS10440 (2086959) 2086959..2087960 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
MUA30_RS10445 (2088309) 2088309..2088671 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA30_RS10450 (2088668) 2088668..2088838 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA30_RS10455 (2088923) 2088923..2090071 - 1149 WP_001281154.1 alanine racemase -
MUA30_RS10460 (2090137) 2090137..2090496 - 360 WP_000581202.1 holo-ACP synthase -
MUA30_RS10465 (2090500) 2090500..2090991 - 492 WP_001205910.1 PH domain-containing protein -
MUA30_RS10470 (2090978) 2090978..2092561 - 1584 WP_262610202.1 PH domain-containing protein -
MUA30_RS10475 (2092554) 2092554..2093033 - 480 WP_262610204.1 hypothetical protein -
MUA30_RS10480 (2093242) 2093242..2093802 - 561 WP_262610206.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T240392 WP_000621175.1 NZ_CP094783:c2088671-2088309 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T240392 NZ_LS998785:2706578-2706685 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGTGTAACCGGAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT240392 WP_000948331.1 NZ_CP094783:c2088838-2088668 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT240392 NZ_LS998785:c2706525-2706464 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References