240391

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 2036857..2037395 Replicon chromosome
Accession NZ_CP094783
Organism Staphylococcus aureus strain IVB6170

Toxin (Protein)


Gene name TscT Uniprot ID -
Locus tag MUA30_RS10175 Protein ID WP_262610176.1
Coordinates 2036857..2037183 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID C5QLS5
Locus tag MUA30_RS10180 Protein ID WP_001058489.1
Coordinates 2037186..2037395 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA30_RS10150 (2032184) 2032184..2032525 - 342 WP_001190600.1 hypothetical protein -
MUA30_RS10155 (2032872) 2032872..2033513 - 642 WP_262610174.1 pathogenicity island protein -
MUA30_RS10160 (2033510) 2033510..2033890 - 381 WP_103145486.1 hypothetical protein -
MUA30_RS10165 (2034198) 2034198..2035907 - 1710 WP_262610175.1 DUF927 domain-containing protein -
MUA30_RS10170 (2035921) 2035921..2036790 - 870 WP_103145484.1 primase alpha helix C-terminal domain-containing protein -
MUA30_RS10175 (2036857) 2036857..2037183 - 327 WP_262610176.1 DUF1474 family protein Toxin
MUA30_RS10180 (2037186) 2037186..2037395 - 210 WP_001058489.1 hypothetical protein Antitoxin
MUA30_RS10185 (2037388) 2037388..2037534 - 147 WP_000784893.1 hypothetical protein -
MUA30_RS10190 (2037531) 2037531..2037848 - 318 WP_103145482.1 helix-turn-helix domain-containing protein -
MUA30_RS10195 (2037852) 2037852..2038064 - 213 WP_262633944.1 helix-turn-helix transcriptional regulator -
MUA30_RS10200 (2038227) 2038227..2038904 + 678 WP_103145480.1 helix-turn-helix transcriptional regulator -
MUA30_RS10205 (2038921) 2038921..2040093 + 1173 WP_262610177.1 site-specific integrase -
MUA30_RS10210 (2040162) 2040162..2041778 - 1617 WP_000240642.1 chaperonin GroEL -
MUA30_RS10215 (2041854) 2041854..2042138 - 285 WP_000917289.1 co-chaperone GroES -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL 2029425..2045109 15684


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 13018.41 Da        Isoelectric Point: 4.6844

>T240391 WP_262610176.1 NZ_CP094783:c2037183-2036857 [Staphylococcus aureus]
MNWEINDLFSDLKVLKDRFEDLKDNHGWHFDNFYPHEANHVLNKTEAIKEGLSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSDVSLATESDDAQKLKITE

Download         Length: 327 bp

>T240391 NZ_LS998785:2706042-2706149 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8225.24 Da        Isoelectric Point: 4.2820

>AT240391 WP_001058489.1 NZ_CP094783:c2037395-2037186 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVDGIEVVSEVSREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT240391 NZ_LS998785:c2705995-2705929 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A853V601

References