Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_XRE(antitoxin) |
| Location | 1551580..1552392 | Replicon | chromosome |
| Accession | NZ_CP094783 | ||
| Organism | Staphylococcus aureus strain IVB6170 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | MUA30_RS07620 | Protein ID | WP_262609859.1 |
| Coordinates | 1551916..1552392 (+) | Length | 159 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | MUA30_RS07615 | Protein ID | WP_045179171.1 |
| Coordinates | 1551580..1551903 (+) | Length | 108 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUA30_RS07540 (1546690) | 1546690..1546950 | - | 261 | WP_000291103.1 | DUF1108 family protein | - |
| MUA30_RS07545 (1547044) | 1547044..1547205 | - | 162 | WP_262609853.1 | DUF1270 domain-containing protein | - |
| MUA30_RS07550 (1547217) | 1547217..1547480 | - | 264 | WP_001124198.1 | helix-turn-helix domain-containing protein | - |
| MUA30_RS07555 (1547630) | 1547630..1547728 | - | 99 | Protein_1482 | hypothetical protein | - |
| MUA30_RS07560 (1547725) | 1547725..1548051 | - | 327 | WP_001025595.1 | hypothetical protein | - |
| MUA30_RS07565 (1548378) | 1548378..1548617 | - | 240 | WP_001294156.1 | hypothetical protein | - |
| MUA30_RS07570 (1548677) | 1548677..1548904 | + | 228 | WP_000801108.1 | hypothetical protein | - |
| MUA30_RS07575 (1548906) | 1548906..1549097 | - | 192 | WP_000389906.1 | hypothetical protein | - |
| MUA30_RS07580 (1549154) | 1549154..1549363 | + | 210 | WP_000772137.1 | hypothetical protein | - |
| MUA30_RS07585 (1549356) | 1549356..1549496 | - | 141 | WP_000939495.1 | hypothetical protein | - |
| MUA30_RS07590 (1549512) | 1549512..1550264 | - | 753 | WP_001148605.1 | phage antirepressor KilAC domain-containing protein | - |
| MUA30_RS07595 (1550320) | 1550320..1550559 | + | 240 | WP_262609855.1 | hypothetical protein | - |
| MUA30_RS07600 (1550749) | 1550749..1550979 | + | 231 | WP_000549548.1 | hypothetical protein | - |
| MUA30_RS07605 (1550976) | 1550976..1551152 | - | 177 | WP_001001356.1 | hypothetical protein | - |
| MUA30_RS07610 (1551168) | 1551168..1551416 | - | 249 | WP_000272859.1 | helix-turn-helix transcriptional regulator | - |
| MUA30_RS07615 (1551580) | 1551580..1551903 | + | 324 | WP_045179171.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| MUA30_RS07620 (1551916) | 1551916..1552392 | + | 477 | WP_262609859.1 | toxin | Toxin |
| MUA30_RS07625 (1552393) | 1552393..1553061 | + | 669 | WP_262609860.1 | Ltp family lipoprotein | - |
| MUA30_RS07630 (1553213) | 1553213..1553395 | + | 183 | WP_000705246.1 | hypothetical protein | - |
| MUA30_RS07635 (1553538) | 1553538..1553765 | - | 228 | WP_162646301.1 | hypothetical protein | - |
| MUA30_RS07640 (1554271) | 1554271..1555476 | + | 1206 | WP_000264190.1 | site-specific integrase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | sak / gnd | 1513528..1578061 | 64533 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 159 a.a. Molecular weight: 18712.19 Da Isoelectric Point: 4.6091
>T240389 WP_262609859.1 NZ_CP094783:1551916-1552392 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSIFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAINYYKKIYGIGTHYGEYSITFEPLRVFKYKKLFEEDI
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSIFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAINYYKKIYGIGTHYGEYSITFEPLRVFKYKKLFEEDI
Download Length: 477 bp
>T240389 NZ_LS998785:2081279-2081382 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
Antitoxin
Download Length: 108 a.a. Molecular weight: 12489.13 Da Isoelectric Point: 8.4338
>AT240389 WP_045179171.1 NZ_CP094783:1551580-1551903 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANELKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANELKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
Download Length: 324 bp
>AT240389 NZ_LS998785:c2081420-2081149 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|