Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 863363..863840 Replicon chromosome
Accession NZ_CP094783
Organism Staphylococcus aureus strain IVB6170

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag MUA30_RS04245 Protein ID WP_000052076.1
Coordinates 863363..863551 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag MUA30_RS04250 Protein ID WP_001059690.1
Coordinates 863580..863840 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA30_RS04215 (859367) 859367..859876 + 510 WP_262611271.1 hypothetical protein -
MUA30_RS04220 (860217) 860217..860903 + 687 WP_262611272.1 thermonuclease family protein -
MUA30_RS04225 (861260) 861260..861460 + 201 WP_001059082.1 cold-shock protein -
MUA30_RS04230 (861954) 861954..862172 - 219 WP_262611274.1 hypothetical protein -
MUA30_RS04235 (862234) 862234..862518 - 285 WP_001004399.1 hypothetical protein -
MUA30_RS04240 (862606) 862606..863175 - 570 WP_262611276.1 lipoprotein N-acylation protein LnsA -
MUA30_RS04245 (863363) 863363..863551 - 189 WP_000052076.1 hypothetical protein Toxin
MUA30_RS04250 (863580) 863580..863840 - 261 WP_001059690.1 hypothetical protein Antitoxin
MUA30_RS04255 (864180) 864180..864383 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
MUA30_RS04260 (864380) 864380..864616 - 237 WP_000368687.1 hypothetical protein -
MUA30_RS04265 (864840) 864840..865421 + 582 WP_262611278.1 histidine phosphatase family protein -
MUA30_RS04270 (865494) 865494..866111 - 618 WP_000255554.1 LysE/ArgO family amino acid transporter -
MUA30_RS04275 (866266) 866266..866760 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
MUA30_RS04280 (867159) 867159..867581 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
MUA30_RS04285 (867729) 867729..868445 + 717 WP_262611280.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-109)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T240383 WP_000052076.1 NZ_CP094783:c863551-863363 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T240383 NZ_LS998785:1053302-1053637 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT240383 WP_001059690.1 NZ_CP094783:c863840-863580 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT240383 NZ_LS998785:1053054-1053302 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References