Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2124686..2125200 Replicon chromosome
Accession NZ_CP094782
Organism Staphylococcus aureus strain IVB6172

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag MUA59_RS10655 Protein ID WP_000581792.1
Coordinates 2124686..2124895 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag MUA59_RS10660 Protein ID WP_000138934.1
Coordinates 2124907..2125200 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA59_RS10635 (MUA59_10605) 2120194..2121552 - 1359 WP_162635984.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
MUA59_RS10640 (MUA59_10610) 2121567..2122637 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
MUA59_RS10645 (MUA59_10615) 2122955..2124157 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
MUA59_RS10650 (MUA59_10620) 2124421..2124558 - 138 WP_000828354.1 Lmo0850 family protein -
MUA59_RS10655 (MUA59_10625) 2124686..2124895 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
MUA59_RS10660 (MUA59_10630) 2124907..2125200 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA59_RS10665 (MUA59_10635) 2125366..2126850 + 1485 WP_000571549.1 cardiolipin synthase -
MUA59_RS10670 (MUA59_10640) 2126878..2127525 + 648 WP_046463185.1 HD domain-containing protein -
MUA59_RS10675 (MUA59_10645) 2128397..2129269 - 873 WP_000725802.1 membrane protein insertase YidC -
MUA59_RS10680 (MUA59_10650) 2129355..2129996 - 642 WP_000483160.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T240373 WP_000581792.1 NZ_CP094782:c2124895-2124686 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T240373 NZ_LS998783:2588872-2589126 [Pseudomonas aeruginosa]
GTGAAGCTGATCTGGTCTGAGCAAGCCTGGGACGATTATCTGTACTGGCAAGAGGCGGATAAGCGTATGGTCAAGAAGCT
CAACGAGCTGATCAAGGAGACCCGCCGCACCCCTTTCGAGGGCAAGGGCAAGCCGGAGCCGCTTCGCCACAACCTGGCGG
GCTTCTGGTCGAGGCGGATCACCGCCGAGCACCGGTTTGTGTATTCGGTGACGGACGAGGCGCTGCTGATTGCCGCCTGC
CGTTATCACTATTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT240373 WP_000138934.1 NZ_CP094782:c2125200-2124907 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT240373 NZ_LS998783:2588624-2588875 [Pseudomonas aeruginosa]
ATGCGCACTATCAGCTATACCGAAGCCCGGCAGAACCTGTCGGCCACCATGGTGCAGACCGTCGAGGATCGCGTGCCTAC
CCTCATTACCCGCCAGAACGGCGAGGCGTGCGTGCTGATGTCGCTGGAGGAGTACAACGCGCTGGAGGAAACGGCTTACC
TGCTGCGCTCGCCGGCCAACGCGCGCCGCCTGATGGATTCGATTGACAGCCTCAAGCGTGGCCAGGGTGTCGAGCGGGAT
ATCGCCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References