Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 2053313..2053842 Replicon chromosome
Accession NZ_CP094782
Organism Staphylococcus aureus strain IVB6172

Toxin (Protein)


Gene name TscT Uniprot ID K7ZRX2
Locus tag MUA59_RS10295 Protein ID WP_001103933.1
Coordinates 2053313..2053630 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A2X2M557
Locus tag MUA59_RS10300 Protein ID WP_001058488.1
Coordinates 2053633..2053842 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA59_RS10270 (MUA59_10240) 2048584..2048925 - 342 WP_001161492.1 hypothetical protein -
MUA59_RS10275 (MUA59_10245) 2049315..2049956 - 642 WP_262537536.1 pathogenicity island protein -
MUA59_RS10280 (MUA59_10250) 2049953..2050333 - 381 WP_000356927.1 hypothetical protein -
MUA59_RS10285 (MUA59_10255) 2050663..2052363 - 1701 WP_262607625.1 DUF927 domain-containing protein -
MUA59_RS10290 (MUA59_10260) 2052377..2053246 - 870 WP_262538431.1 primase alpha helix C-terminal domain-containing protein -
MUA59_RS10295 (MUA59_10265) 2053313..2053630 - 318 WP_001103933.1 DUF1474 family protein Toxin
MUA59_RS10300 (MUA59_10270) 2053633..2053842 - 210 WP_001058488.1 hypothetical protein Antitoxin
MUA59_RS10305 (MUA59_10275) 2053835..2053981 - 147 WP_076742779.1 pathogenicity island protein -
MUA59_RS10310 (MUA59_10280) 2053978..2054295 - 318 WP_000481967.1 helix-turn-helix domain-containing protein -
MUA59_RS10315 (MUA59_10285) 2054300..2054518 - 219 WP_000153640.1 helix-turn-helix transcriptional regulator -
MUA59_RS10320 (MUA59_10290) 2054691..2055365 + 675 WP_262538429.1 helix-turn-helix transcriptional regulator -
MUA59_RS10325 (MUA59_10295) 2055379..2056551 + 1173 WP_262607626.1 site-specific integrase -
MUA59_RS10330 (MUA59_10300) 2056621..2058237 - 1617 WP_000240642.1 chaperonin GroEL -
MUA59_RS10335 (MUA59_10305) 2058312..2058596 - 285 WP_000917289.1 co-chaperone GroES -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL 2039341..2058596 19255


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12511.13 Da        Isoelectric Point: 4.6364

>T240371 WP_001103933.1 NZ_CP094782:c2053630-2053313 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE

Download         Length: 318 bp

>T240371 NZ_LS998783:2091513-2092100 [Pseudomonas aeruginosa]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGGCGTTGCCGCTCGCCGTCCGCCTCGGCGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAATTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGAGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8287.31 Da        Isoelectric Point: 4.2820

>AT240371 WP_001058488.1 NZ_CP094782:c2053842-2053633 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT240371 NZ_LS998783:2092167-2093021 [Pseudomonas aeruginosa]
GTGCCGGACGAGACGAGCGGAGAACATACGCATTTCTGGCGCGCCGCCGAACTGGGCGGCGTCGAGTTGCTGCATGCGCG
CTACGTCGAGCAGCGTTTCGCCCCCCATGTGCACAGCGGCTTCGCCCTGGTCTTCATCGAGCAGGGCGCGCAGCGCTTCC
GCCATCGCGGCGGCGAGCACCTGGCGCCCTGGGGCAGCATGGTGCTGATCAACCCCGACGAAGTGCACACCGGCTCCAAG
GCCCATGACTCCGGCTGGCTCTATCGCGGCTACTACCCGGAGGTGGAGCAGATCGCCAGTATCCTCGACGAGCTGGAAAT
CCGCCACGGCGGGGTGCCGCGTTTCGCCGACAGCGTGGTCCATGACCAGCCCCTGGCGCGCGCCTTCGTCCATCTGCACC
GCTTGCTGGCCGACCACGCCGGCAGCCTGGAAACCCAGACCTGCTGGCGCGAGACGCTGCTCGCCCTGTTCCGTCGCCAC
GCCCGCCTGCCGGAGGCGCCGAAGGCCGGGTCGGAACCGTTGGCGGTCGCCCGCGCCCGCGAGTTGCTGGCGGCGCGTTT
GCTCGACCCGCCGTCGCTGGAAGAACTGGCGGCTGCGGTGAATCTGTCGCCGTTCCACTTCGCCCGGGTGTTCCGCCGCG
CCACCGGGATGCCGCCGCATGCCTGGCTCCGGCAACGGCGCCTGGAACAGGCCAGGGCGCTGCTCAAGAATGGCCGGGCG
CCGCTGGATGTCGCCCTGGAACTGGGCTTCGCCGACCAGAGCCATCTCGGTCGCCAGTTCAAGCAGGCCTACGGCGTGGC
GCCGGGCGAGTACCGCGCGGCCTGTGCGCGCTCGTCCTTGACGATGTGCGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7ZRX2

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2M557

References