Detailed information of TA system TA240370

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1886818..1887594
• Replicon: chromosome
• Accession: NZ_CP094782
• Organism: Staphylococcus aureus strain IVB6172

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: MUA59_RS09210
• Protein ID: WP_197805632.1
• Coordinates: 1886818..1886970 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: A0A0D1IYN8
• Locus tag: MUA59_RS09215
• Protein ID: WP_001251219.1
• Coordinates: 1886995..1887594 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA59_RS09190 (MUA59_09165)	1881866..1882978	-	1113	WP_000437967.1	GAF domain-containing sensor histidine kinase	-
MUA59_RS09195 (MUA59_09170)	1883141..1883962	+	822	WP_000669377.1	RluA family pseudouridine synthase	-
MUA59_RS09200 (MUA59_09175)	1884411..1885796	-	1386	WP_262607582.1	class II fumarate hydratase	-
MUA59_RS09205 (MUA59_09180)	1885992..1886387	-	396	WP_000901023.1	hypothetical protein	-
MUA59_RS09210 (MUA59_09185)	1886818..1886970	-	153	WP_197805632.1	SAS053 family protein	Toxin
MUA59_RS09215 (MUA59_09190)	1886995..1887594	-	600	WP_001251219.1	glucosamine-6-phosphate isomerase	Antitoxin
MUA59_RS09220 (MUA59_09195)	1887753..1888223	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
MUA59_RS09225 (MUA59_09200)	1888228..1889355	-	1128	WP_262607584.1	tRNA epoxyqueuosine(34) reductase QueG	-
MUA59_RS09230 (MUA59_09205)	1889506..1890228	-	723	WP_192860286.1	amino acid ABC transporter ATP-binding protein	-
MUA59_RS09235 (MUA59_09210)	1890221..1891678	-	1458	WP_262607585.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5922.25 Da
• Isoelectric Point: 3.8849

>T240370 WP_197805632.1 NZ_CP094782:c1886970-1886818 [Staphylococcus aureus]
MSKDKDPKLNYHDEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T240370 NZ_LS998783:c1175075-1174002 [Pseudomonas aeruginosa]
GTGACTGAACGCGACTACAAAAACATCAACCTCAAACGATGCATTATCGAGGAAACGACTCATTGCTTCATCCGAGATAA
TGGCCTGAAGCTGCGATCCTATGGTGACAAGCCTGGGAGTTCCGGTCTTCGAGTAGTCTTCGGAAAAGCAGGGATTGAAG
ATGCCACGCTTGATATTTTTTTCACGAATGTCGGTGCGTCTACCCTGACCTACAAGGTGGGCAAGAACCAAGCTCTCGGC
CAGCAGCTAGCGGATGCTCTTTACGAAACAATCCACCCCGATGAATTCGTAACGATGAACCTTGGTATCAAAGGCGTCGA
TCTGGATGATGCCGAAGCCCTTATCAAGGAACTCACTGAGTCAGCCAATGCGGACATTGAGGTTGCTTCGCGCACAAGCG
CTGATCGCAAGCATATTTGGAAGCTCAAGTCTAAAAAGAACTTGGATGAGTTGACTGTCACTCAGCACGAGAACACCCAT
AAACTGCAGATCCAGGGTCGTCCTCTCAGCTGCTATCAGCAGTTGAGCTACCTGCTCACCGAGCTCCTAGAGATCAACGC
ACTCGAATGCATCCTGTTCAAAAAGGAAGAAAATCGCTCGGAGTTCGTTTGTGCCGAGGTCGCGGAAAGCGTACTCAAGG
AAAGGTTTGGCGACTGCTACGCCAACCTGCCACAGACCTCGCGTAGGCTGCTCCTGGCAAGCCTTTGCGTGAGGCTTGCC
AGCCCCGCGCTACCCGACTACTGCATGCTGGTTTATCCGGAACTCCGCACCCTTGAAGGCGCGATCAAACAGAAGCTTGC
AGAAAAAAACCTTTCAAATCAGGAAGAAAGCTTCGGTGGCTTCTTTACCAAGACCAATGGTCAGTTTTATCTGAAGCAGC
AATACCATGCTGATGTCGGCGATGCTAAACTACAGGGTCATCTGGACAACGCTTACACCTTCTTCAACAAGCAACGCCAC
GGATTGTTCCACATGGAAGAGATGCCATCCGTTAGTCGAATGATTAGCAACATCACCCAAGCTGTGTCATTGTGTGATGA
AGCATATGATCATATCAAGAATTTGTATAGCTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22357.50 Da
• Isoelectric Point: 5.1445

>AT240370 WP_001251219.1 NZ_CP094782:c1887594-1886995 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT240370 NZ_LS998783:c1173947-1173654 [Pseudomonas aeruginosa]
ATGACGGTAGTTACCGCTACCAGTTATGAGAACCCCTTATCTCGTCTTTCTATTATTGCTAGCGAGATGCGCAATACATC
TCACTCCAGCAAGGAGATAGTTCTATTCGATCTACTCTGCTCTAACGGAGAAGAGTGGAATCGTTTCGTCTCCATCAATT
ACAACGGCACCGACTTCGAAAAAAGCACCTGTAGCATTGTCTCCAAGTCCGACATCCCTACAGACCTCTTGGAAACACAA
ACTCGCTTCTTTCAAATCCATCCACAATATCTGCTTGATTCAGTTTTGAATTAA

Structures

Antitoxin

• AlphaFold DB: A0A0D1IYN8