Detailed information of TA system TA240367

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 846399..846876
• Replicon: chromosome
• Accession: NZ_CP094782
• Organism: Staphylococcus aureus strain IVB6172

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: MUA59_RS04075
• Protein ID: WP_000052076.1
• Coordinates: 846399..846587 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: MUA59_RS04080
• Protein ID: WP_001059690.1
• Coordinates: 846616..846876 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA59_RS04045 (MUA59_04030)	842390..842911	+	522	WP_262537147.1	hypothetical protein	-
MUA59_RS04050 (MUA59_04035)	843252..843938	+	687	WP_001641381.1	thermonuclease family protein	-
MUA59_RS04055 (MUA59_04040)	844295..844495	+	201	WP_001059082.1	cold-shock protein	-
MUA59_RS04060 (MUA59_04045)	844990..845208	-	219	WP_000005880.1	hypothetical protein	-
MUA59_RS04065 (MUA59_04050)	845270..845554	-	285	WP_262607946.1	hypothetical protein	-
MUA59_RS04070 (MUA59_04055)	845642..846211	-	570	WP_001106648.1	lipoprotein N-acylation protein LnsA	-
MUA59_RS04075 (MUA59_04060)	846399..846587	-	189	WP_000052076.1	hypothetical protein	Toxin
MUA59_RS04080 (MUA59_04065)	846616..846876	-	261	WP_001059690.1	hypothetical protein	Antitoxin
MUA59_RS04085 (MUA59_04070)	847217..847420	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
MUA59_RS04090 (MUA59_04075)	847417..847653	-	237	WP_000368687.1	hypothetical protein	-
MUA59_RS04095 (MUA59_04080)	847878..848459	+	582	WP_001140691.1	histidine phosphatase family protein	-
MUA59_RS04100 (MUA59_04085)	848532..849149	-	618	WP_262613897.1	LysE/ArgO family amino acid transporter	-
MUA59_RS04105 (MUA59_04090)	849305..849799	-	495	WP_000569881.1	GNAT family N-acetyltransferase	-
MUA59_RS04110 (MUA59_04095)	850198..850620	-	423	WP_262607948.1	organic hydroperoxide resistance protein	-
MUA59_RS04115 (MUA59_04100)	850768..851484	+	717	WP_262537141.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (6-81)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T240367 WP_000052076.1 NZ_CP094782:c846587-846399 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T240367 NZ_LS997868:614755-615021 [Vibrio cholerae]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
GTTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCGGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT240367 WP_001059690.1 NZ_CP094782:c846876-846616 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT240367 NZ_LS997868:615008-615253 [Vibrio cholerae]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGGGTCAATGTGGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGCCAATCAATCATTAAAATTTGGTTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56