Detailed information of TA system TA240366

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 398530..399041
• Replicon: chromosome
• Accession: NZ_CP094782
• Organism: Staphylococcus aureus strain IVB6172

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: MUA59_RS01810
• Protein ID: WP_001103943.1
• Coordinates: 398742..399041 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: MUA59_RS01805
• Protein ID: WP_001058486.1
• Coordinates: 398530..398739 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA59_RS01770 (MUA59_01755)	393883..394872	-	990	WP_250425947.1	Abi family protein	-
MUA59_RS01775 (MUA59_01760)	394878..396092	-	1215	WP_262607853.1	site-specific integrase	-
MUA59_RS01780 (MUA59_01765)	396096..396908	-	813	WP_049948385.1	hypothetical protein	-
MUA59_RS01785 (MUA59_01770)	397022..397717	-	696	WP_031903008.1	helix-turn-helix transcriptional regulator	-
MUA59_RS01790 (MUA59_01775)	397862..398074	+	213	WP_000608987.1	hypothetical protein	-
MUA59_RS01795 (MUA59_01780)	398107..398379	+	273	WP_262607854.1	helix-turn-helix domain-containing protein	-
MUA59_RS01800 (MUA59_01785)	398391..398537	+	147	WP_000784875.1	hypothetical protein	-
MUA59_RS01805 (MUA59_01790)	398530..398739	+	210	WP_001058486.1	hypothetical protein	Antitoxin
MUA59_RS01810 (MUA59_01795)	398742..399041	+	300	WP_001103943.1	DUF1474 family protein	Toxin
MUA59_RS01815 (MUA59_01800)	399116..400732	+	1617	WP_103144518.1	phage resistance protein	-
MUA59_RS01820 (MUA59_01805)	400908..401711	+	804	WP_196251784.1	bifunctional DNA primase/polymerase	-
MUA59_RS01825 (MUA59_01810)	401698..401970	+	273	WP_001149387.1	hypothetical protein	-
MUA59_RS01830 (MUA59_01815)	401972..402613	+	642	WP_262607855.1	pathogenicity island protein	-
MUA59_RS01835 (MUA59_01820)	403003..403344	+	342	WP_001161492.1	hypothetical protein	-
MUA59_RS01840 (MUA59_01825)	403356..403934	+	579	WP_000846290.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	tsst-1	392555..414956	22401

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11795.24 Da
• Isoelectric Point: 4.5689

>T240366 WP_001103943.1 NZ_CP094782:398742-399041 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFDELIQKF
HEIEKASSDVSLATESDDA

Nucleotide

• Length: 300 bp

>T240366 NZ_LS997868:c610684-610394 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTACCACTCCAACAGCAGTTCAA
GAACAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACAGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT240366 WP_001058486.1 NZ_CP094782:398530-398739 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT240366 NZ_LS997868:c610922-610674 [Vibrio cholerae]
ATGACCACCAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGCGC
CTTCGGAGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTATGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA