Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2137131..2137645 Replicon chromosome
Accession NZ_CP094780
Organism Staphylococcus aureus strain IVB6173

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag MUA18_RS10480 Protein ID WP_000581792.1
Coordinates 2137131..2137340 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag MUA18_RS10485 Protein ID WP_000138934.1
Coordinates 2137352..2137645 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA18_RS10460 (MUA18_10455) 2132639..2133997 - 1359 WP_000611474.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
MUA18_RS10465 (MUA18_10460) 2134012..2135082 - 1071 WP_262543012.1 D-alanine--D-alanine ligase -
MUA18_RS10470 (MUA18_10465) 2135400..2136602 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
MUA18_RS10475 (MUA18_10470) 2136866..2137003 - 138 WP_000828354.1 Lmo0850 family protein -
MUA18_RS10480 (MUA18_10475) 2137131..2137340 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
MUA18_RS10485 (MUA18_10480) 2137352..2137645 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA18_RS10490 (MUA18_10485) 2137811..2139295 + 1485 WP_000571557.1 cardiolipin synthase -
MUA18_RS10495 (MUA18_10490) 2139323..2139970 + 648 WP_001187631.1 HD domain-containing protein -
MUA18_RS10500 (MUA18_10495) 2140736..2141608 - 873 WP_000725802.1 membrane protein insertase YidC -
MUA18_RS10505 (MUA18_10500) 2141694..2142335 - 642 WP_000483148.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T240361 WP_000581792.1 NZ_CP094780:c2137340-2137131 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T240361 NZ_LS997868:c580755-580456 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCATGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCCGAGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT240361 WP_000138934.1 NZ_CP094780:c2137645-2137352 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT240361 NZ_LS997868:c580994-580752 [Vibrio cholerae]
ATGGCTAAAAACACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGACGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAATTAC
TTGTTGAAGGTGAGCAAAGTGGTGATGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References