Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1959433..1960209 Replicon chromosome
Accession NZ_CP094780
Organism Staphylococcus aureus strain IVB6173

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag MUA18_RS09480 Protein ID WP_000031108.1
Coordinates 1959433..1959585 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag MUA18_RS09485 Protein ID WP_001251219.1
Coordinates 1959610..1960209 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA18_RS09465 (MUA18_09460) 1955437..1956258 + 822 WP_000669377.1 RluA family pseudouridine synthase -
MUA18_RS09470 (MUA18_09465) 1956708..1958093 - 1386 WP_000116236.1 class II fumarate hydratase -
MUA18_RS09475 (MUA18_09470) 1958289..1958684 - 396 WP_000901023.1 hypothetical protein -
MUA18_RS09480 (MUA18_09475) 1959433..1959585 - 153 WP_000031108.1 SAS053 family protein Toxin
MUA18_RS09485 (MUA18_09480) 1959610..1960209 - 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
MUA18_RS09490 (MUA18_09485) 1960368..1960838 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MUA18_RS09495 (MUA18_09490) 1960843..1961970 - 1128 WP_000379981.1 tRNA epoxyqueuosine(34) reductase QueG -
MUA18_RS09500 (MUA18_09495) 1962121..1962843 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
MUA18_RS09505 (MUA18_09500) 1962836..1964293 - 1458 WP_262541880.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T240359 WP_000031108.1 NZ_CP094780:c1959585-1959433 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T240359 NZ_LS997868:574069-574323 [Vibrio cholerae]
ATGAGAATCGTTTCTTTTACAGAAGCTAGGAATAGTTTAAAAGCAGTCTTGGATGCTGTTGTGAATGATGCGGATACAAC
CGTCATCACTCGACGTGATTCAGAAGATGCCGTGGTTATGTCGCTGGATTATTACAATAGTCTAATGGAAACCGTACATT
TGCTTCGCTCTCCAGCGAACGCTGAACATCTAAACCGTTCCATTGCCCAGTTCAAAGCGGGAAAAGTTACCCAAAGAGAT
CTGATTGATGAGTAG

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT240359 WP_001251219.1 NZ_CP094780:c1960209-1959610 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT240359 NZ_LS997868:574316-574579 [Vibrio cholerae]
ATGAGTAGTCGTTTACTGTCATGGACAGATGAGTCCTGGGATGACTACTTGTACTGGCAAACACAAGACAAAAAAACACT
CAAGCGGATCAATAAAATCATCAATGATGTTAAGCGTTCACCGTTTGAAGGTATTGGTAAACCAGAGCCTCTAAAAGAAA
ATCTATCTGGTTTTTGGTCTCGACGGATCGATGACACAAATAGACTGGTTTATGCTGTTGATGATAATGCAATAACGATT
ATTTCGTGTCGCTACCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References