Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1582695..1583492 Replicon chromosome
Accession NZ_CP094780
Organism Staphylococcus aureus strain IVB6173

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA18_RS07610 Protein ID WP_262541840.1
Coordinates 1583031..1583492 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA18_RS07605 Protein ID WP_001260486.1
Coordinates 1582695..1583018 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA18_RS07555 (MUA18_07550) 1578430..1578987 - 558 WP_000645049.1 DUF2815 family protein -
MUA18_RS07560 (MUA18_07555) 1579014..1580180 - 1167 WP_233665663.1 DUF2800 domain-containing protein -
MUA18_RS07565 (MUA18_07560) 1580177..1580539 - 363 WP_000985986.1 hypothetical protein -
MUA18_RS07570 (MUA18_07565) 1580554..1580877 - 324 WP_000175000.1 hypothetical protein -
MUA18_RS07575 (MUA18_07570) 1580956..1581117 - 162 WP_001285954.1 DUF1270 domain-containing protein -
MUA18_RS07580 (MUA18_07575) 1581130..1581393 - 264 WP_001124160.1 helix-turn-helix domain-containing protein -
MUA18_RS07585 (MUA18_07580) 1581418..1581633 - 216 WP_001097552.1 hypothetical protein -
MUA18_RS07590 (MUA18_07585) 1581688..1582053 + 366 WP_001128433.1 hypothetical protein -
MUA18_RS07595 (MUA18_07590) 1582022..1582267 - 246 WP_001025401.1 DUF2829 domain-containing protein -
MUA18_RS07600 (MUA18_07595) 1582283..1582531 - 249 WP_000272861.1 helix-turn-helix domain-containing protein -
MUA18_RS07605 (MUA18_07600) 1582695..1583018 + 324 WP_001260486.1 helix-turn-helix transcriptional regulator Antitoxin
MUA18_RS07610 (MUA18_07605) 1583031..1583492 + 462 WP_262541840.1 toxin Toxin
MUA18_RS07615 (MUA18_07610) 1583510..1583944 + 435 WP_031903825.1 hypothetical protein -
MUA18_RS07620 (MUA18_07615) 1583972..1584367 + 396 WP_001558060.1 hypothetical protein -
MUA18_RS07625 (MUA18_07620) 1584475..1584666 + 192 WP_252559444.1 hypothetical protein -
MUA18_RS07630 (MUA18_07625) 1584663..1585241 - 579 WP_252559441.1 hypothetical protein -
MUA18_RS07635 (MUA18_07630) 1585367..1586572 + 1206 WP_000264747.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1538899..1604203 65304


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18062.40 Da        Isoelectric Point: 4.6915

>T240358 WP_262541840.1 NZ_CP094780:1583031-1583492 [Staphylococcus aureus]
MGLYEETLIQHDYIETREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T240358 NZ_LS997868:572241-572528 [Vibrio cholerae]
ATGACTTATAAATTAAAGTTTTTGCCAGCAGCCCAAAAGGAGTGGAGTAAGCTAGCGCCAACGATTCAGAGTCAATTTAA
AAAGAAACTCAAAGAAAGGCTAGAAAACCCCCACGTCCCATCATCAAAATTACGAGGTTATGATTCTGTTTACAAAATCA
AACTTCGTACATCTGGTTATCGTTTGGCTTATGAAGTCATCGATAATGAAGTTGTCGTTTATGTACTCGCTGTTGGTAAA
CGAGACAAAGACGCTGTTTATAAAAAGCTGGCTTCACGCTTCAGCTAG

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12427.10 Da        Isoelectric Point: 9.3811

>AT240358 WP_001260486.1 NZ_CP094780:1582695-1583018 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQPENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 324 bp

>AT240358 NZ_LS997868:572000-572251 [Vibrio cholerae]
ATGAGACAGGTATTAGCAAATTGCTCTGCCAGTATTTCAGAGTTAAAGAAAAATCCAACGGCTCTTTTGAACGAGGCTGA
TGGTTCAGCTATTGCGATCCTTAACCACAACAAACCGGCAGCTTACCTTGTACCGGCTGAAACTTACGAGTATCTGATGG
ATATGCTTGATGATTATGAGCTTTCCCAAATAGTAGATAGTCGTCGTGGTGATTTGTCGCAAGCTGTGGAAATCAATATT
GATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References