Detailed information of TA system TA240354

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 871229..871706
• Replicon: chromosome
• Accession: NZ_CP094780
• Organism: Staphylococcus aureus strain IVB6173

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: MUA18_RS04170
• Protein ID: WP_000052076.1
• Coordinates: 871229..871417 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: MUA18_RS04175
• Protein ID: WP_001059690.1
• Coordinates: 871446..871706 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA18_RS04140 (MUA18_04135)	867218..867739	+	522	WP_000824476.1	hypothetical protein	-
MUA18_RS04145 (MUA18_04140)	868080..868766	+	687	WP_262542240.1	thermonuclease family protein	-
MUA18_RS04150 (MUA18_04145)	869123..869323	+	201	WP_001059082.1	cold-shock protein	-
MUA18_RS04155 (MUA18_04150)	869820..870038	-	219	WP_000005883.1	hypothetical protein	-
MUA18_RS04160 (MUA18_04155)	870100..870384	-	285	WP_001004401.1	hypothetical protein	-
MUA18_RS04165 (MUA18_04160)	870472..871041	-	570	WP_001106648.1	lipoprotein N-acylation protein LnsA	-
MUA18_RS04170 (MUA18_04165)	871229..871417	-	189	WP_000052076.1	hypothetical protein	Toxin
MUA18_RS04175 (MUA18_04170)	871446..871706	-	261	WP_001059690.1	hypothetical protein	Antitoxin
MUA18_RS04180 (MUA18_04175)	872047..872250	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
MUA18_RS04185 (MUA18_04180)	872247..872483	-	237	WP_000368687.1	hypothetical protein	-
MUA18_RS04190 (MUA18_04185)	872708..873289	+	582	WP_001140696.1	histidine phosphatase family protein	-
MUA18_RS04195 (MUA18_04190)	873362..873979	-	618	WP_000255565.1	LysE/ArgO family amino acid transporter	-
MUA18_RS04200 (MUA18_04195)	874135..874629	-	495	WP_000569881.1	GNAT family N-acetyltransferase	-
MUA18_RS04205 (MUA18_04200)	875028..875450	-	423	WP_000974462.1	organic hydroperoxide resistance protein	-
MUA18_RS04210 (MUA18_04205)	875598..876314	+	717	WP_262542244.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	865863..895888	30025

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T240354 WP_000052076.1 NZ_CP094780:c871417-871229 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T240354 NZ_LS997868:551124-551426 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCCGGCTCTATCCGATCTGAATGATATTGCTGAATACATCGCACTTGAAAATGTCGT
GGCCGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCAC
CAGAACTAGAACACCTTAATTATCGTGAAGTCGTTGTAAATCCATGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT240354 WP_001059690.1 NZ_CP094780:c871706-871446 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT240354 NZ_LS997868:550879-551136 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGGCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAGCCGTCAGCTTACCTTATTGATGTAGACGATTATGAATTTATGCAAAATCGTTTAGCGA
TCCTCGAAGGCATTGCTCGTGGCGAGCGAGCTCTAGCGGATGGCAAAGTGGTTAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56