Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2199001..2199515 Replicon chromosome
Accession NZ_CP094778
Organism Staphylococcus aureus strain IVB6185

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag MUA10_RS10920 Protein ID WP_000581791.1
Coordinates 2199001..2199210 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag MUA10_RS10925 Protein ID WP_000138934.1
Coordinates 2199222..2199515 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA10_RS10895 (MUA10_10890) 2194358..2195560 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
MUA10_RS10900 (MUA10_10895) 2195721..2195930 - 210 Protein_2104 transposase -
MUA10_RS10905 (MUA10_10900) 2195992..2197638 - 1647 WP_000277709.1 IS1182-like element ISSau3 family transposase -
MUA10_RS10910 (MUA10_10905) 2197915..2198324 - 410 Protein_2106 transposase -
MUA10_RS10915 (MUA10_10910) 2198736..2198873 - 138 WP_000828354.1 Lmo0850 family protein -
MUA10_RS10920 (MUA10_10915) 2199001..2199210 - 210 WP_000581791.1 heavy metal-associated domain-containing protein Toxin
MUA10_RS10925 (MUA10_10920) 2199222..2199515 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA10_RS10930 (MUA10_10925) 2199681..2201165 + 1485 WP_000571560.1 cardiolipin synthase -
MUA10_RS10935 (MUA10_10930) 2201193..2201840 + 648 WP_001187612.1 HD domain-containing protein -
MUA10_RS10940 (MUA10_10935) 2202553..2203425 - 873 WP_000725802.1 membrane protein insertase YidC -
MUA10_RS10945 (MUA10_10940) 2203511..2204152 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T240348 WP_000581791.1 NZ_CP094778:c2199210-2199001 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T240348 NZ_LS992193:c98675-98370 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCTGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGTTGTCAGATAAGGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAGGAAGTG
GCTGATCTCAGCCACCGAGAAAATGACATCAAAAATGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT240348 WP_000138934.1 NZ_CP094778:c2199515-2199222 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT240348 NZ_LS992193:c98895-98677 [Escherichia coli]
ATGAAGCAGCGCATTACAGTCACCGTCGACAGTGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGGCT
GGTAAGCACCACCCTGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCAGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References