Detailed information of TA system TA240339

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 917597..918074
• Replicon: chromosome
• Accession: NZ_CP094778
• Organism: Staphylococcus aureus strain IVB6185

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: MUA10_RS04475
• Protein ID: WP_000052076.1
• Coordinates: 917597..917785 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: MUA10_RS04480
• Protein ID: WP_001059690.1
• Coordinates: 917814..918074 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA10_RS04445 (MUA10_04440)	913550..914107	+	558	WP_045178710.1	hypothetical protein	-
MUA10_RS04450 (MUA10_04445)	914448..915134	+	687	WP_001574556.1	thermonuclease family protein	-
MUA10_RS04455 (MUA10_04450)	915491..915691	+	201	WP_001059082.1	cold-shock protein	-
MUA10_RS04460 (MUA10_04455)	916188..916406	-	219	WP_000005879.1	hypothetical protein	-
MUA10_RS04465 (MUA10_04460)	916468..916752	-	285	WP_001004401.1	hypothetical protein	-
MUA10_RS04470 (MUA10_04465)	916840..917409	-	570	WP_001106663.1	lipoprotein N-acylation protein LnsA	-
MUA10_RS04475 (MUA10_04470)	917597..917785	-	189	WP_000052076.1	hypothetical protein	Toxin
MUA10_RS04480 (MUA10_04475)	917814..918074	-	261	WP_001059690.1	hypothetical protein	Antitoxin
MUA10_RS04485 (MUA10_04480)	918415..918618	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
MUA10_RS04490 (MUA10_04485)	918615..918851	-	237	WP_000368687.1	hypothetical protein	-
MUA10_RS04495 (MUA10_04490)	919076..919657	+	582	WP_001140696.1	histidine phosphatase family protein	-
MUA10_RS04500 (MUA10_04495)	919730..920347	-	618	WP_000255548.1	LysE/ArgO family amino acid transporter	-
MUA10_RS04505 (MUA10_04500)	920503..920997	-	495	WP_000569884.1	GNAT family N-acetyltransferase	-
MUA10_RS04510 (MUA10_04505)	921396..921818	-	423	WP_000974455.1	organic hydroperoxide resistance protein	-
MUA10_RS04515 (MUA10_04510)	921966..922682	+	717	WP_250396435.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	tsst-1 / vWbp	885419..928409	42990

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (7-88)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (37-93)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T240339 WP_000052076.1 NZ_CP094778:c917785-917597 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T240339 NZ_LS992192:c4373496-4373209 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCC
TGGTTCACGGTATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGCCGCTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT240339 WP_001059690.1 NZ_CP094778:c918074-917814 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT240339 NZ_LS992192:c4373222-4372920 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACACCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCACTGGCGAA
TAAATTCGACGAAGATATTGATTACAGTGATATCCCGCCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACCCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGCTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56