Detailed information of TA system TA240338

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 440463..441001
• Replicon: chromosome
• Accession: NZ_CP094778
• Organism: Staphylococcus aureus strain IVB6185

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: MUA10_RS02100
• Protein ID: WP_045178601.1
• Coordinates: 440675..441001 (+)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: MUA10_RS02095
• Protein ID: WP_045178599.1
• Coordinates: 440463..440672 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA10_RS02055 (MUA10_02055)	435477..436376	-	900	WP_045179037.1	Abi family protein	-
MUA10_RS02060 (MUA10_02060)	436378..437592	-	1215	WP_250396273.1	site-specific integrase	-
MUA10_RS02065 (MUA10_02065)	437871..438500	-	630	WP_231858805.1	XRE family transcriptional regulator	-
MUA10_RS02070 (MUA10_02070)	438523..439047	-	525	Protein_411	SAP domain protein	-
MUA10_RS02075 (MUA10_02075)	439074..439646	-	573	WP_001186980.1	helix-turn-helix transcriptional regulator	-
MUA10_RS02080 (MUA10_02080)	439818..440039	+	222	WP_000560872.1	helix-turn-helix transcriptional regulator	-
MUA10_RS02085 (MUA10_02085)	440040..440312	+	273	WP_000124597.1	helix-turn-helix domain-containing protein	-
MUA10_RS02090 (MUA10_02090)	440324..440470	+	147	WP_000784893.1	hypothetical protein	-
MUA10_RS02095 (MUA10_02095)	440463..440672	+	210	WP_045178599.1	hypothetical protein	Antitoxin
MUA10_RS02100 (MUA10_02100)	440675..441001	+	327	WP_045178601.1	DUF1474 family protein	Toxin
MUA10_RS02105 (MUA10_02105)	441066..441935	+	870	WP_045178602.1	primase alpha helix C-terminal domain-containing protein	-
MUA10_RS02110 (MUA10_02110)	441949..443658	+	1710	WP_250396272.1	DUF927 domain-containing protein	-
MUA10_RS02115 (MUA10_02115)	443969..444349	+	381	WP_000356932.1	hypothetical protein	-
MUA10_RS02120 (MUA10_02120)	444346..444987	+	642	WP_045178603.1	pathogenicity island protein	-
MUA10_RS02125 (MUA10_02125)	445335..445676	+	342	WP_001190600.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	430381..455556	25175

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-100)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 13093.44 Da
• Isoelectric Point: 4.6496

>T240338 WP_045178601.1 NZ_CP094778:440675-441001 [Staphylococcus aureus]
MNLEINDLFSDLKLLKDRFEDLKDSHGWHFEELYPHEPNHNLNKDELIREGFSYHERRIHNNQMFDLFHLYIEQFDKIIE
KFHEIEKASSENFGEESDDAKNSIKVAE

Nucleotide

• Length: 327 bp

>T240338 NZ_LS992192:c4263218-4262934 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGATAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAATGA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8220.25 Da
• Isoelectric Point: 4.3718

>AT240338 WP_045178599.1 NZ_CP094778:440463-440672 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELILKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT240338 NZ_LS992192:c4263454-4263221 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG