Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2131334..2131848 Replicon chromosome
Accession NZ_CP094775
Organism Staphylococcus aureus strain IVB6191

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag MUA69_RS10645 Protein ID WP_000581792.1
Coordinates 2131334..2131543 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag MUA69_RS10650 Protein ID WP_000138934.1
Coordinates 2131555..2131848 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA69_RS10625 (MUA69_10600) 2126842..2128200 - 1359 WP_262607637.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
MUA69_RS10630 (MUA69_10605) 2128215..2129285 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
MUA69_RS10635 (MUA69_10610) 2129603..2130805 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
MUA69_RS10640 (MUA69_10615) 2131069..2131206 - 138 WP_000828354.1 Lmo0850 family protein -
MUA69_RS10645 (MUA69_10620) 2131334..2131543 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
MUA69_RS10650 (MUA69_10625) 2131555..2131848 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA69_RS10655 (MUA69_10630) 2132014..2133498 + 1485 WP_000571549.1 cardiolipin synthase -
MUA69_RS10660 (MUA69_10635) 2133526..2134173 + 648 WP_046463185.1 HD domain-containing protein -
MUA69_RS10665 (MUA69_10640) 2135045..2135917 - 873 WP_000725802.1 membrane protein insertase YidC -
MUA69_RS10670 (MUA69_10645) 2136003..2136644 - 642 WP_000483160.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T240334 WP_000581792.1 NZ_CP094775:c2131543-2131334 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T240334 NZ_LS992192:2924341-2924448 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT240334 WP_000138934.1 NZ_CP094775:c2131848-2131555 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT240334 NZ_LS992192:c2924284-2924229 [Escherichia coli]
CAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References