240332

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 2059961..2060490 Replicon chromosome
Accession NZ_CP094775
Organism Staphylococcus aureus strain IVB6191

Toxin (Protein)


Gene name TscT Uniprot ID K7ZRX2
Locus tag MUA69_RS10285 Protein ID WP_001103933.1
Coordinates 2059961..2060278 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A2X2M557
Locus tag MUA69_RS10290 Protein ID WP_001058488.1
Coordinates 2060281..2060490 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA69_RS10260 (MUA69_10235) 2055232..2055573 - 342 WP_001161492.1 hypothetical protein -
MUA69_RS10265 (MUA69_10240) 2055963..2056604 - 642 WP_262537536.1 pathogenicity island protein -
MUA69_RS10270 (MUA69_10245) 2056601..2056981 - 381 WP_000356927.1 hypothetical protein -
MUA69_RS10275 (MUA69_10250) 2057311..2059011 - 1701 WP_262607625.1 DUF927 domain-containing protein -
MUA69_RS10280 (MUA69_10255) 2059025..2059894 - 870 WP_262538431.1 primase alpha helix C-terminal domain-containing protein -
MUA69_RS10285 (MUA69_10260) 2059961..2060278 - 318 WP_001103933.1 DUF1474 family protein Toxin
MUA69_RS10290 (MUA69_10265) 2060281..2060490 - 210 WP_001058488.1 hypothetical protein Antitoxin
MUA69_RS10295 (MUA69_10270) 2060483..2060629 - 147 WP_076742779.1 pathogenicity island protein -
MUA69_RS10300 (MUA69_10275) 2060626..2060943 - 318 WP_000481967.1 helix-turn-helix domain-containing protein -
MUA69_RS10305 (MUA69_10280) 2060948..2061166 - 219 WP_000153640.1 helix-turn-helix transcriptional regulator -
MUA69_RS10310 (MUA69_10285) 2061339..2062013 + 675 WP_262538429.1 helix-turn-helix transcriptional regulator -
MUA69_RS10315 (MUA69_10290) 2062027..2063199 + 1173 WP_262607626.1 site-specific integrase -
MUA69_RS10320 (MUA69_10295) 2063269..2064885 - 1617 WP_000240642.1 chaperonin GroEL -
MUA69_RS10325 (MUA69_10300) 2064960..2065244 - 285 WP_000917289.1 co-chaperone GroES -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL 2045989..2065244 19255


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12511.13 Da        Isoelectric Point: 4.6364

>T240332 WP_001103933.1 NZ_CP094775:c2060278-2059961 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE

Download         Length: 318 bp

>T240332 NZ_LS992192:2335440-2335542 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8287.31 Da        Isoelectric Point: 4.2820

>AT240332 WP_001058488.1 NZ_CP094775:c2060490-2060281 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT240332 NZ_LS992192:c2335580-2335312 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7ZRX2

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2M557

References