Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1893455..1894231 Replicon chromosome
Accession NZ_CP094775
Organism Staphylococcus aureus strain IVB6191

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag MUA69_RS09200 Protein ID WP_197805632.1
Coordinates 1893455..1893607 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag MUA69_RS09205 Protein ID WP_262607583.1
Coordinates 1893632..1894231 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA69_RS09180 (MUA69_09160) 1888502..1889614 - 1113 WP_000437967.1 GAF domain-containing sensor histidine kinase -
MUA69_RS09185 (MUA69_09165) 1889777..1890598 + 822 WP_000669377.1 RluA family pseudouridine synthase -
MUA69_RS09190 (MUA69_09170) 1891048..1892433 - 1386 WP_262607582.1 class II fumarate hydratase -
MUA69_RS09195 (MUA69_09175) 1892629..1893024 - 396 WP_000901023.1 hypothetical protein -
MUA69_RS09200 (MUA69_09180) 1893455..1893607 - 153 WP_197805632.1 SAS053 family protein Toxin
MUA69_RS09205 (MUA69_09185) 1893632..1894231 - 600 WP_262607583.1 glucosamine-6-phosphate isomerase Antitoxin
MUA69_RS09210 (MUA69_09190) 1894390..1894860 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MUA69_RS09215 (MUA69_09195) 1894865..1895992 - 1128 WP_262607584.1 tRNA epoxyqueuosine(34) reductase QueG -
MUA69_RS09220 (MUA69_09200) 1896143..1896865 - 723 WP_192860286.1 amino acid ABC transporter ATP-binding protein -
MUA69_RS09225 (MUA69_09205) 1896858..1898315 - 1458 WP_262607585.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5922.25 Da        Isoelectric Point: 3.8849

>T240331 WP_197805632.1 NZ_CP094775:c1893607-1893455 [Staphylococcus aureus]
MSKDKDPKLNYHDEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T240331 NZ_LS992192:c1983809-1983435 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCAGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22385.55 Da        Isoelectric Point: 5.1445

>AT240331 WP_262607583.1 NZ_CP094775:c1894231-1893632 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYVADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT240331 NZ_LS992192:c1984266-1983898 [Escherichia coli]
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References