Detailed information of TA system TA240328

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 852023..852500
• Replicon: chromosome
• Accession: NZ_CP094775
• Organism: Staphylococcus aureus strain IVB6191

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: MUA69_RS04080
• Protein ID: WP_000052076.1
• Coordinates: 852023..852211 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: MUA69_RS04085
• Protein ID: WP_001059690.1
• Coordinates: 852240..852500 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA69_RS04050 (MUA69_04035)	848014..848535	+	522	WP_262537147.1	hypothetical protein	-
MUA69_RS04055 (MUA69_04040)	848876..849562	+	687	WP_001641381.1	thermonuclease family protein	-
MUA69_RS04060 (MUA69_04045)	849919..850119	+	201	WP_001059082.1	cold-shock protein	-
MUA69_RS04065 (MUA69_04050)	850614..850832	-	219	WP_000005880.1	hypothetical protein	-
MUA69_RS04070 (MUA69_04055)	850894..851178	-	285	WP_262607946.1	hypothetical protein	-
MUA69_RS04075 (MUA69_04060)	851266..851835	-	570	WP_001106648.1	lipoprotein N-acylation protein LnsA	-
MUA69_RS04080 (MUA69_04065)	852023..852211	-	189	WP_000052076.1	hypothetical protein	Toxin
MUA69_RS04085 (MUA69_04070)	852240..852500	-	261	WP_001059690.1	hypothetical protein	Antitoxin
MUA69_RS04090 (MUA69_04075)	852841..853044	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
MUA69_RS04095 (MUA69_04080)	853041..853277	-	237	WP_000368687.1	hypothetical protein	-
MUA69_RS04100 (MUA69_04085)	853502..854083	+	582	WP_001140691.1	histidine phosphatase family protein	-
MUA69_RS04105 (MUA69_04090)	854156..854773	-	618	WP_262607947.1	LysE/ArgO family amino acid transporter	-
MUA69_RS04110 (MUA69_04095)	854929..855423	-	495	WP_000569881.1	GNAT family N-acetyltransferase	-
MUA69_RS04115 (MUA69_04100)	855822..856244	-	423	WP_262607948.1	organic hydroperoxide resistance protein	-
MUA69_RS04120 (MUA69_04105)	856392..857108	+	717	WP_262537141.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T240328 WP_000052076.1 NZ_CP094775:c852211-852023 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T240328 NZ_LS992192:952519-952926 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT240328 WP_001059690.1 NZ_CP094775:c852500-852240 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT240328 NZ_LS992192:952272-952538 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCACCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56