Detailed information of TA system TA240327

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 398882..399393
• Replicon: chromosome
• Accession: NZ_CP094775
• Organism: Staphylococcus aureus strain IVB6191

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: MUA69_RS01795
• Protein ID: WP_001103943.1
• Coordinates: 399094..399393 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: MUA69_RS01790
• Protein ID: WP_001058486.1
• Coordinates: 398882..399091 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA69_RS01755 (MUA69_01745)	394235..395224	-	990	WP_250425947.1	Abi family protein	-
MUA69_RS01760 (MUA69_01750)	395230..396444	-	1215	WP_262607853.1	site-specific integrase	-
MUA69_RS01765 (MUA69_01755)	396448..397260	-	813	WP_049948385.1	hypothetical protein	-
MUA69_RS01770 (MUA69_01760)	397374..398069	-	696	WP_031903008.1	helix-turn-helix transcriptional regulator	-
MUA69_RS01775 (MUA69_01765)	398214..398426	+	213	WP_000608987.1	hypothetical protein	-
MUA69_RS01780 (MUA69_01770)	398459..398731	+	273	WP_262607854.1	helix-turn-helix domain-containing protein	-
MUA69_RS01785 (MUA69_01775)	398743..398889	+	147	WP_000784875.1	hypothetical protein	-
MUA69_RS01790 (MUA69_01780)	398882..399091	+	210	WP_001058486.1	hypothetical protein	Antitoxin
MUA69_RS01795 (MUA69_01785)	399094..399393	+	300	WP_001103943.1	DUF1474 family protein	Toxin
MUA69_RS01800 (MUA69_01790)	399468..401084	+	1617	WP_103144518.1	phage resistance protein	-
MUA69_RS01805 (MUA69_01795)	401260..402063	+	804	WP_196251784.1	bifunctional DNA primase/polymerase	-
MUA69_RS01810 (MUA69_01800)	402050..402322	+	273	WP_001149387.1	hypothetical protein	-
MUA69_RS01815 (MUA69_01805)	402324..402965	+	642	WP_262607855.1	pathogenicity island protein	-
MUA69_RS01820 (MUA69_01810)	403355..403696	+	342	WP_001161492.1	hypothetical protein	-
MUA69_RS01825 (MUA69_01815)	403708..404286	+	579	WP_000846290.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	tsst-1	393224..415308	22084

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11795.24 Da
• Isoelectric Point: 4.5689

>T240327 WP_001103943.1 NZ_CP094775:399094-399393 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFDELIQKF
HEIEKASSDVSLATESDDA

Nucleotide

• Length: 300 bp

>T240327 NZ_LS992192:c807556-807179 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCAGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT240327 WP_001058486.1 NZ_CP094775:398882-399091 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT240327 NZ_LS992192:c808013-807645 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGTACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACCGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA