Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2155213..2155727 Replicon chromosome
Accession NZ_CP094773
Organism Staphylococcus aureus strain IVB6195

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag MUA47_RS10630 Protein ID WP_000603099.1
Coordinates 2155213..2155422 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag MUA47_RS10635 Protein ID WP_000138933.1
Coordinates 2155434..2155727 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA47_RS10610 (2150721) 2150721..2152079 - 1359 WP_000611466.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
MUA47_RS10615 (2152094) 2152094..2153164 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
MUA47_RS10620 (2153482) 2153482..2154684 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
MUA47_RS10625 (2154948) 2154948..2155085 - 138 WP_000828354.1 Lmo0850 family protein -
MUA47_RS10630 (2155213) 2155213..2155422 - 210 WP_000603099.1 heavy metal-associated domain-containing protein Toxin
MUA47_RS10635 (2155434) 2155434..2155727 - 294 WP_000138933.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA47_RS10640 (2155893) 2155893..2157377 + 1485 WP_250425847.1 cardiolipin synthase -
MUA47_RS10645 (2157405) 2157405..2158067 + 663 WP_262634660.1 HD domain-containing protein -
MUA47_RS10650 (2158624) 2158624..2159490 - 867 WP_064139140.1 membrane protein insertase YidC -
MUA47_RS10655 (2159576) 2159576..2160217 - 642 WP_000483158.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7819.79 Da        Isoelectric Point: 3.9389

>T240323 WP_000603099.1 NZ_CP094773:c2155422-2155213 [Staphylococcus aureus]
MILQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T240323 NZ_LS992192:186695-186802 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.81 Da        Isoelectric Point: 6.7122

>AT240323 WP_000138933.1 NZ_CP094773:c2155727-2155434 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNKGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT240323 NZ_LS992192:c186638-186581 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References