Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2135469..2135998 Replicon chromosome
Accession NZ_CP094773
Organism Staphylococcus aureus strain IVB6195

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MUA47_RS10540 Protein ID WP_000621175.1
Coordinates 2135469..2135831 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag MUA47_RS10545 Protein ID WP_000948331.1
Coordinates 2135828..2135998 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA47_RS10520 (2132448) 2132448..2133218 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
MUA47_RS10525 (2133193) 2133193..2133672 - 480 WP_001190825.1 anti-sigma B factor RsbW -
MUA47_RS10530 (2133674) 2133674..2134000 - 327 WP_001052491.1 anti-sigma factor antagonist -
MUA47_RS10535 (2134119) 2134119..2135120 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
MUA47_RS10540 (2135469) 2135469..2135831 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA47_RS10545 (2135828) 2135828..2135998 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA47_RS10550 (2136083) 2136083..2137231 - 1149 WP_250425843.1 alanine racemase -
MUA47_RS10555 (2137297) 2137297..2137656 - 360 WP_000581198.1 holo-ACP synthase -
MUA47_RS10560 (2137660) 2137660..2138151 - 492 WP_001205919.1 PH domain-containing protein -
MUA47_RS10565 (2138138) 2138138..2139721 - 1584 WP_250425846.1 PH domain-containing protein -
MUA47_RS10570 (2139714) 2139714..2140193 - 480 WP_001287083.1 hypothetical protein -
MUA47_RS10575 (2140402) 2140402..2140962 - 561 WP_001092415.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T240322 WP_000621175.1 NZ_CP094773:c2135831-2135469 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T240322 NZ_LS992192:186212-186319 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT240322 WP_000948331.1 NZ_CP094773:c2135998-2135828 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT240322 NZ_LS992192:c186163-186098 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References