Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1976042..1976818 Replicon chromosome
Accession NZ_CP094773
Organism Staphylococcus aureus strain IVB6195

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag MUA47_RS09630 Protein ID WP_000031108.1
Coordinates 1976042..1976194 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag MUA47_RS09635 Protein ID WP_001251219.1
Coordinates 1976219..1976818 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA47_RS09615 (1972133) 1972133..1972954 + 822 WP_000669377.1 RluA family pseudouridine synthase -
MUA47_RS09620 (1973405) 1973405..1974790 - 1386 WP_262633469.1 class II fumarate hydratase -
MUA47_RS09625 (1974986) 1974986..1975381 - 396 WP_000901023.1 hypothetical protein -
MUA47_RS09630 (1976042) 1976042..1976194 - 153 WP_000031108.1 SAS053 family protein Toxin
MUA47_RS09635 (1976219) 1976219..1976818 - 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
MUA47_RS09640 (1976977) 1976977..1977447 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MUA47_RS09645 (1977452) 1977452..1978579 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
MUA47_RS09650 (1978730) 1978730..1979452 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
MUA47_RS09655 (1979445) 1979445..1980902 - 1458 WP_103153007.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T240321 WP_000031108.1 NZ_CP094773:c1976194-1976042 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T240321 NZ_LS992191:83873-84178 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT240321 WP_001251219.1 NZ_CP094773:c1976818-1976219 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT240321 NZ_LS992191:83653-83871 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References