Detailed information of TA system TA240314

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 910375..910913
• Replicon: chromosome
• Accession: NZ_CP094773
• Organism: Staphylococcus aureus strain IVB6195

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: MUA47_RS04415
• Protein ID: WP_045178618.1
• Coordinates: 910587..910913 (+)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: MUA47_RS04410
• Protein ID: WP_045178617.1
• Coordinates: 910375..910584 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA47_RS04375 (906238)	906238..907458	-	1221	WP_262515151.1	site-specific integrase	-
MUA47_RS04380 (907669)	907669..908349	-	681	WP_250406351.1	type II toxin-antitoxin system PemK/MazF family toxin	-
MUA47_RS04385 (908489)	908489..908656	-	168	WP_031806878.1	hypothetical protein	-
MUA47_RS04390 (908853)	908853..909491	-	639	WP_250425963.1	XRE family transcriptional regulator	-
MUA47_RS04395 (909682)	909682..909936	+	255	WP_250425964.1	helix-turn-helix transcriptional regulator	-
MUA47_RS04400 (909952)	909952..910224	+	273	WP_250425965.1	helix-turn-helix domain-containing protein	-
MUA47_RS04405 (910236)	910236..910382	+	147	WP_250406348.1	pathogenicity island protein	-
MUA47_RS04410 (910375)	910375..910584	+	210	WP_045178617.1	hypothetical protein	Antitoxin
MUA47_RS04415 (910587)	910587..910913	+	327	WP_045178618.1	DUF1474 family protein	Toxin
MUA47_RS04420 (910977)	910977..911846	+	870	WP_045178619.1	primase alpha helix C-terminal domain-containing protein	-
MUA47_RS04425 (911863)	911863..913320	+	1458	WP_045178620.1	virulence-associated E family protein	-
MUA47_RS04430 (913621)	913621..913983	+	363	WP_045178622.1	hypothetical protein	-
MUA47_RS04435 (913985)	913985..914269	+	285	WP_045178623.1	hypothetical protein	-
MUA47_RS04440 (914266)	914266..914908	+	643	Protein_863	pathogenicity island protein	-
MUA47_RS04445 (915256)	915256..915597	+	342	WP_001190600.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	906238..921666	15428

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-100)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 13165.42 Da
• Isoelectric Point: 4.5527

>T240314 WP_045178618.1 NZ_CP094773:910587-910913 [Staphylococcus aureus]
MNWEINDLFSDLKVLKDRFEDLKDNHGWHFEELYPHEPNHNLNKDELIREGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFHEIEKASSENFGEESDDAKNSIKVAE

Nucleotide

• Length: 327 bp

>T240314 NZ_LS992190:c4396098-4395721 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8237.34 Da
• Isoelectric Point: 4.6311

>AT240314 WP_045178617.1 NZ_CP094773:910375-910584 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLKLSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT240314 NZ_LS992190:c4396556-4396188 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA