Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 893600..894077 Replicon chromosome
Accession NZ_CP094773
Organism Staphylococcus aureus strain IVB6195

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag MUA47_RS04280 Protein ID WP_000052076.1
Coordinates 893600..893788 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag MUA47_RS04285 Protein ID WP_001059690.1
Coordinates 893817..894077 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA47_RS04250 (889639) 889639..890109 + 471 WP_000824470.1 hypothetical protein -
MUA47_RS04255 (890450) 890450..891136 + 687 WP_001804081.1 thermonuclease family protein -
MUA47_RS04260 (891493) 891493..891693 + 201 WP_001059082.1 cold-shock protein -
MUA47_RS04265 (892191) 892191..892409 - 219 WP_250425959.1 hypothetical protein -
MUA47_RS04270 (892471) 892471..892755 - 285 WP_001004401.1 hypothetical protein -
MUA47_RS04275 (892843) 892843..893412 - 570 WP_262634772.1 lipoprotein N-acylation protein LnsA -
MUA47_RS04280 (893600) 893600..893788 - 189 WP_000052076.1 hypothetical protein Toxin
MUA47_RS04285 (893817) 893817..894077 - 261 WP_001059690.1 hypothetical protein Antitoxin
MUA47_RS04290 (894418) 894418..894621 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
MUA47_RS04295 (894618) 894618..894854 - 237 WP_000368687.1 hypothetical protein -
MUA47_RS04300 (895079) 895079..895660 + 582 WP_001140691.1 histidine phosphatase family protein -
MUA47_RS04305 (895733) 895733..896350 - 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
MUA47_RS04310 (896506) 896506..897000 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
MUA47_RS04315 (897399) 897399..897821 - 423 WP_000974454.1 organic hydroperoxide resistance protein -
MUA47_RS04320 (897969) 897969..898685 + 717 WP_250425960.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(19-121)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T240313 WP_000052076.1 NZ_CP094773:c893788-893600 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T240313 NZ_LS992190:4364352-4364609 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT240313 WP_001059690.1 NZ_CP094773:c894077-893817 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT240313 NZ_LS992190:4364621-4365172 [Escherichia coli]
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References