Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2154845..2155359 Replicon chromosome
Accession NZ_CP094772
Organism Staphylococcus aureus strain IVB6196

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag MUA50_RS10780 Protein ID WP_000581791.1
Coordinates 2154845..2155054 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag MUA50_RS10785 Protein ID WP_000138934.1
Coordinates 2155066..2155359 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA50_RS10760 (2150734) 2150734..2151804 - 1071 WP_000159638.1 D-alanine--D-alanine ligase -
MUA50_RS10765 (2152122) 2152122..2153324 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
MUA50_RS10770 (2153485) 2153485..2154168 - 684 Protein_2083 transposase -
MUA50_RS10775 (2154580) 2154580..2154717 - 138 WP_000828354.1 Lmo0850 family protein -
MUA50_RS10780 (2154845) 2154845..2155054 - 210 WP_000581791.1 heavy metal-associated domain-containing protein Toxin
MUA50_RS10785 (2155066) 2155066..2155359 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA50_RS10790 (2155525) 2155525..2157009 + 1485 WP_000571560.1 cardiolipin synthase -
MUA50_RS10795 (2157037) 2157037..2157684 + 648 WP_001187612.1 HD domain-containing protein -
MUA50_RS10800 (2158297) 2158297..2159169 - 873 WP_000725802.1 membrane protein insertase YidC -
MUA50_RS10805 (2159255) 2159255..2159896 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T240301 WP_000581791.1 NZ_CP094772:c2155054-2154845 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T240301 NZ_LS992190:1037453-1037860 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT240301 WP_000138934.1 NZ_CP094772:c2155359-2155066 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT240301 NZ_LS992190:1037206-1037472 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCACCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References