Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 1235742..1236290 Replicon chromosome
Accession NC_012943
Organism Mycobacterium tuberculosis KZN 1435

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag TBMG_RS05725 Protein ID WP_003414602.1
Coordinates 1235742..1236005 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag TBMG_RS05730 Protein ID WP_003414599.1
Coordinates 1236009..1236290 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBMG_RS05705 1230816..1232057 + 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
TBMG_RS05710 1232065..1233279 + 1215 WP_003899518.1 zinc metalloprotease Rip -
TBMG_RS05715 1233296..1234459 + 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
TBMG_RS05720 1234515..1235369 + 855 WP_003899516.1 GNAT family N-acetyltransferase -
TBMG_RS05725 1235742..1236005 - 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
TBMG_RS05730 1236009..1236290 - 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
TBMG_RS05735 1236562..1238373 + 1812 WP_003906921.1 penicillin-binding protein -
TBMG_RS05740 1238455..1238835 - 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
TBMG_RS05745 1238832..1239080 - 249 WP_003913411.1 antitoxin VapB23 -
TBMG_RS05750 1239184..1239768 + 585 WP_003899514.1 DUF1707 domain-containing protein -
TBMG_RS05755 1239810..1240667 + 858 WP_003899513.1 type I methionyl aminopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T24030 WP_003414602.1 NC_012943:c1236005-1235742 [Mycobacterium tuberculosis KZN 1435]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

>T24030 NC_012943:c1236005-1235742 [Mycobacterium tuberculosis KZN 1435]
GTGCCTTACACCGTGCGGTTCACCACAACCGCGCGTCGAGACCTCCACAAGCTGCCACCGCGAATCCTCGCGGCAGTGGT
CGAATTCGCGTTCGGCGATCTGTCGCGCGAGCCCCTGCGGGTGGGCAAGCCCCTTCGGCGCGAGTTGGCCGGCACGTTCA
GCGCGCGTCGCGGAACGTACCGCCTGCTGTACCGGATTGACGACGAGCACACAACGGTAGTGATCCTGCGCGTCGATCAC
CGCGCGGACATCTACCGCCGATAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT24030 WP_003414599.1 NC_012943:c1236290-1236009 [Mycobacterium tuberculosis KZN 1435]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp

>AT24030 NC_012943:c1236290-1236009 [Mycobacterium tuberculosis KZN 1435]
ATGCGGATACTGCCGATTTCGACGATCAAGGGCAAGCTCAATGAGTTCGTCGACGCGGTCTCGTCGACACAGGACCAGAT
CACCATCACCAAGAACGGTGCACCCGCAGCCGTTCTGGTCGGCGCCGACGAGTGGGAATCGTTGCAGGAGACGCTGTACT
GGCTGGCGCAACCCGGAATCAGGGAGTCGATCGCTGAAGCCGACGCCGACATTGCCTCCGGCCGCACCTACGGCGAAGAC
GAGATCCGCGCCGAATTCGGCGTCCCGCGACGCCCCCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
PDB 3G5O
AlphaFold DB A0A7U4BWP8

References