240299

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 2080619..2081133 Replicon chromosome
Accession NZ_CP094772
Organism Staphylococcus aureus strain IVB6196

Toxin (Protein)


Gene name TscT Uniprot ID -
Locus tag MUA50_RS10410 Protein ID WP_262515866.1
Coordinates 2080619..2080921 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID -
Locus tag MUA50_RS10415 Protein ID WP_262515867.1
Coordinates 2080918..2081133 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA50_RS10380 (2075768) 2075768..2076346 - 579 WP_262515861.1 pathogenicity island protein -
MUA50_RS10385 (2076358) 2076358..2076699 - 342 WP_262540013.1 pathogenicity island protein -
MUA50_RS10390 (2077047) 2077047..2077688 - 642 WP_262515863.1 pathogenicity island protein -
MUA50_RS10395 (2077690) 2077690..2077962 - 273 WP_111762498.1 pathogenicity island protein -
MUA50_RS10400 (2077949) 2077949..2078752 - 804 WP_000148373.1 bifunctional DNA primase/polymerase -
MUA50_RS10405 (2078928) 2078928..2080544 - 1617 WP_262515864.1 phage resistance protein -
MUA50_RS10410 (2080619) 2080619..2080921 - 303 WP_262515866.1 DUF1474 family protein Toxin
MUA50_RS10415 (2080918) 2080918..2081133 - 216 WP_262515867.1 pathogenicity island protein Antitoxin
MUA50_RS10420 (2081126) 2081126..2081272 - 147 WP_000784893.1 hypothetical protein -
MUA50_RS10425 (2081269) 2081269..2081586 - 318 WP_262540014.1 helix-turn-helix domain-containing protein -
MUA50_RS10430 (2081602) 2081602..2081802 - 201 WP_111762499.1 helix-turn-helix transcriptional regulator -
MUA50_RS10435 (2081965) 2081965..2082642 + 678 WP_111762500.1 helix-turn-helix transcriptional regulator -
MUA50_RS10440 (2082659) 2082659..2083831 + 1173 WP_111762501.1 tyrosine-type recombinase/integrase -
MUA50_RS10445 (2083900) 2083900..2085516 - 1617 WP_262515869.1 chaperonin GroEL -
MUA50_RS10450 (2085592) 2085592..2085876 - 285 WP_000917289.1 co-chaperone GroES -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL 2071189..2085876 14687


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 12181.39 Da        Isoelectric Point: 4.6906

>T240299 WP_262515866.1 NZ_CP094772:c2080921-2080619 [Staphylococcus aureus]
MNWEINDLFSDLKVLKDRFEDLKDNHGWHFDNFYPHEPNHVLNKTEAIKEGLSYHERRIHNNQMFDLFHLYIEQFDKIIE
KFHEIEKASSENFGEESDDA

Download         Length: 303 bp

>T240299 NZ_LS992190:c888604-887711 [Escherichia coli]
ATGCCTGAATTAACATCATTATTTCCTGACGTTGCCGATGCACTGGATATTGAATCTGTCGCTATCGTCGAAAAAGATTA
TTTTGTGGTTGATCTTTTAAGATTATTAAAAGAAATAAAACCAGAAACACATACTCTCGTGTTTGCAGGTAGTACCGCAT
TATCAAAAGCAGGTATCTCGCTAAACAGAATGTCAGAAGATATTGATATAAAGCTCGTGCCAACAGAGAACTTTATGCAA
AATGGCAGAGACAAGAGAAGAAAAATTCGCAAGGAAATCGTGCAAATAATCACGGATGTTATTCATAATTCTGACATTTT
CAGCTTGGATAATGAAAACGCCCGTATAACACGTGATGAGTATCGTTATAACGAAATCTCGGTACGTTATCCCCAGACAT
TTGCACAAGTCCCCTGTCTTCGTCCATTTATTAAGCTGGAGTTGATGGAAAGCACTCTGCTGGAACATCCGGAAAGCAGA
GATATTTATTCCCTTGTAACGGAGTTAACGGGTAAAGGTACACCTATAACAGCATTCCCCTGTGCCACCATTTTATCCAC
TCAGGCTGAAAAGCTCATCTCCATGATGCGAAGAACAGCAGCACATCTTCGTAATCCCGAACAACAGGATGATGAGTTTC
TGGTACGTCACATTTATGACAACTACTGCATTGTCAGGGAAAAAGGTGTGAATGTTCCTGTATTGAAAAATTTTGTTCAG
ATATGTATTCAACAGGATATTGAACGCTATGGTAACCAGTACCCACAATTTTGTAGCTCACCAGTTGATGAACTTAAGAA
AGGGCTGGATGCACTCCGGGATTATCCTGTACACAAATTGCGCTTTCAACGATTTGTTAACCCGATGGTATTTGGTAATA
CACAGATTAACTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8494.58 Da        Isoelectric Point: 4.5099

>AT240299 WP_262515867.1 NZ_CP094772:c2081133-2080918 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGEQK

Download         Length: 216 bp

>AT240299 NZ_LS992190:c888992-888597 [Escherichia coli]
ATGACTACAAAAGACCGTATTCAGTCCCGACTGAACCGTTCAAAACGTTATGTGTTCACCCGGGATGATTTCAGGGATAT
CGCTGGCTATGATCAGGTTGGCAGAGCTCTTCGTACACTGGTAAACGAAGGTAAGTTGATGAAAGTGGGCTATGGTGTTT
ACACCAAAGCCCGTCGTAACATCATCACTGGGAAAATCATGCCCGCAGCGCCTGGGGGCTCTGCTGCAGTAATTACAGAG
GCCCTGGAGCGCCTGAATATCAGATACCGTCTGGCAGGAGCAACGGAATGCTACAATAAAGGTCAGTCCACACAAATTCC
TGTATCTCTGGGGATAAAAACACCTTCTCGATTTAAAAGAGTGTTAATAGTAGGGAAAAGTAAAATCAATGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References