Detailed information of TA system TA240295

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_XRE(antitoxin)
• Location: 1366385..1367182
• Replicon: chromosome
• Accession: NZ_CP094772
• Organism: Staphylococcus aureus strain IVB6196

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: MUA50_RS06955
• Protein ID: WP_262540173.1
• Coordinates: 1366385..1366846 (-)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A0C2LD36
• Locus tag: MUA50_RS06960
• Protein ID: WP_001260487.1
• Coordinates: 1366859..1367182 (-)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA50_RS06930 (1362022)	1362022..1362273	+	252	WP_262540169.1	hypothetical protein	-
MUA50_RS06935 (1362331)	1362331..1364064	+	1734	WP_262540170.1	hypothetical protein	-
MUA50_RS06940 (1364107)	1364107..1365312	-	1206	WP_262540171.1	site-specific integrase	-
MUA50_RS06945 (1365438)	1365438..1366016	+	579	WP_252559441.1	hypothetical protein	-
MUA50_RS06950 (1366013)	1366013..1366204	-	192	WP_252559444.1	hypothetical protein	-
MUA50_RS06955 (1366385)	1366385..1366846	-	462	WP_262540173.1	toxin	Toxin
MUA50_RS06960 (1366859)	1366859..1367182	-	324	WP_001260487.1	helix-turn-helix transcriptional regulator	Antitoxin
MUA50_RS06965 (1367347)	1367347..1367595	+	249	WP_262515396.1	helix-turn-helix transcriptional regulator	-
MUA50_RS06970 (1367611)	1367611..1368408	+	798	WP_262540175.1	phage antirepressor KilAC domain-containing protein	-
MUA50_RS06975 (1368575)	1368575..1368805	-	231	WP_000395455.1	hypothetical protein	-
MUA50_RS06980 (1368866)	1368866..1368964	+	99	Protein_1334	hypothetical protein	-
MUA50_RS06985 (1369114)	1369114..1369377	+	264	WP_001124185.1	helix-turn-helix domain-containing protein	-
MUA50_RS06990 (1369390)	1369390..1369467	+	78	Protein_1336	hypothetical protein	-
MUA50_RS06995 (1369482)	1369482..1369694	-	213	WP_000461464.1	hypothetical protein	-
MUA50_RS07000 (1369765)	1369765..1369995	+	231	WP_096659904.1	hypothetical protein	-
MUA50_RS07005 (1369979)	1369979..1370149	+	171	WP_001837399.1	DUF1270 domain-containing protein	-
MUA50_RS07010 (1370130)	1370130..1370468	+	339	WP_250405827.1	XRE family transcriptional regulator	-
MUA50_RS07015 (1370544)	1370544..1370861	+	318	WP_000829612.1	hypothetical protein	-
MUA50_RS07020 (1370854)	1370854..1371156	+	303	WP_077534991.1	DUF2482 family protein	-
MUA50_RS07025 (1371161)	1371161..1371421	+	261	WP_262540180.1	DUF1108 family protein	-
MUA50_RS07030 (1371436)	1371436..1371915	+	480	WP_000002516.1	siphovirus Gp157 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (8-65)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 18118.47 Da
• Isoelectric Point: 4.6915

>T240295 WP_262540173.1 NZ_CP094772:c1366846-1366385 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYLLEAIEQYKKIYGIGTHYGEYSITFEPLRVYRYKEI

Nucleotide

• Length: 462 bp

>T240295 NZ_LS992190:256050-256157 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12431.09 Da
• Isoelectric Point: 9.3811

>AT240295 WP_001260487.1 NZ_CP094772:c1367182-1366859 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Nucleotide

• Length: 324 bp

>AT240295 NZ_LS992190:c255993-255936 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Antitoxin

• AlphaFold DB: A0A0C2LD36