Detailed information of TA system TA240291

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 875110..875648
• Replicon: chromosome
• Accession: NZ_CP094772
• Organism: Staphylococcus aureus strain IVB6196

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: MUA50_RS04255
• Protein ID: WP_262516296.1
• Coordinates: 875322..875648 (+)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: MUA50_RS04250
• Protein ID: WP_250406114.1
• Coordinates: 875110..875319 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA50_RS04215 (870973)	870973..872193	-	1221	WP_262515151.1	site-specific integrase	-
MUA50_RS04220 (872404)	872404..873084	-	681	WP_262519410.1	type II toxin-antitoxin system PemK/MazF family toxin	-
MUA50_RS04225 (873224)	873224..873391	-	168	WP_031806878.1	hypothetical protein	-
MUA50_RS04230 (873588)	873588..874226	-	639	WP_250406350.1	XRE family transcriptional regulator	-
MUA50_RS04235 (874417)	874417..874671	+	255	WP_250425964.1	helix-turn-helix transcriptional regulator	-
MUA50_RS04240 (874687)	874687..874959	+	273	WP_250425965.1	helix-turn-helix domain-containing protein	-
MUA50_RS04245 (874971)	874971..875117	+	147	WP_250406348.1	pathogenicity island protein	-
MUA50_RS04250 (875110)	875110..875319	+	210	WP_250406114.1	pathogenicity island protein	Antitoxin
MUA50_RS04255 (875322)	875322..875648	+	327	WP_262516296.1	DUF1474 family protein	Toxin
MUA50_RS04260 (875713)	875713..876582	+	870	WP_262516297.1	primase alpha helix C-terminal domain-containing protein	-
MUA50_RS04265 (876599)	876599..878068	+	1470	WP_262516298.1	virulence-associated E family protein	-
MUA50_RS04270 (878348)	878348..878710	+	363	WP_045178622.1	hypothetical protein	-
MUA50_RS04275 (878712)	878712..878975	+	264	WP_001804819.1	hypothetical protein	-
MUA50_RS04280 (878977)	878977..879618	+	642	WP_252580283.1	pathogenicity island protein	-
MUA50_RS04285 (879965)	879965..880306	+	342	WP_262516299.1	pathogenicity island protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	853089..893355	40266

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-100)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 12978.31 Da
• Isoelectric Point: 4.7152

>T240291 WP_262516296.1 NZ_CP094772:875322-875648 [Staphylococcus aureus]
MNLEINDLFSDLKLLKDRFEDLKDNHGWHFDNFYPHEPNHVLNKTEAIKEGLSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFHEIEKASSENFGEESDDAKNSIKVAE

Nucleotide

• Length: 327 bp

>T240291 NZ_LS992189:c39664-39404 [Escherichia coli]
ATGAAGATAAGAAAAGGTGACAGACAATATTATCTGAATAAAGAAGGTGATACGTTTCATCTGGTGAAGCGAGTAAAAAC
TTTTTCTAAGTCTGCGACTTTAGGAAAAACGAAAGCAACGGTGAAAACTGTTGCTGATCTTGTTTTTCATGAGAAGGCAT
TCGACACTATCGACTTTGCCAGCGACGGATTAAGAGATAATGATAAAGAAATTGTTTTTATGATGATTCAGGAAATGAGC
GAAGAAGAAAATGCTAACTGA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8220.25 Da
• Isoelectric Point: 4.3718

>AT240291 WP_250406114.1 NZ_CP094772:875110-875319 [Staphylococcus aureus]
MNNEQKEVLEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELILKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT240291 NZ_LS992189:c39414-39175 [Escherichia coli]
ATGCTAACTGAAAACACACCAGAAAACATTAAGCGTCTGCGGAAAAAAATTGGCCTGACACAGAAAGAATGTGCCGAAAT
ATTCAGCATGAGTCCGCGTACATGGCGTCGTAAAGAAGAACCTGTCGGAACTGCAAGCGGTACAGCACTTACACCCGTGG
AGTTTAAATATCTTCTGCTTTTAGCTGGGGAACATCCTGAATACGTCCTTAGTAAAAGAGATCGAGGAATTTTAAAATGA