Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 858492..858969 Replicon chromosome
Accession NZ_CP094772
Organism Staphylococcus aureus strain IVB6196

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag MUA50_RS04120 Protein ID WP_000052076.1
Coordinates 858492..858680 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag MUA50_RS04125 Protein ID WP_001059690.1
Coordinates 858709..858969 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA50_RS04090 (854445) 854445..855002 + 558 WP_000824491.1 hypothetical protein -
MUA50_RS04095 (855343) 855343..856029 + 687 WP_001574556.1 thermonuclease family protein -
MUA50_RS04100 (856386) 856386..856586 + 201 WP_001059082.1 cold-shock protein -
MUA50_RS04105 (857083) 857083..857301 - 219 WP_000005879.1 hypothetical protein -
MUA50_RS04110 (857363) 857363..857647 - 285 WP_001004401.1 hypothetical protein -
MUA50_RS04115 (857735) 857735..858304 - 570 WP_001106663.1 lipoprotein N-acylation protein LnsA -
MUA50_RS04120 (858492) 858492..858680 - 189 WP_000052076.1 hypothetical protein Toxin
MUA50_RS04125 (858709) 858709..858969 - 261 WP_001059690.1 hypothetical protein Antitoxin
MUA50_RS04130 (859310) 859310..859513 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
MUA50_RS04135 (859510) 859510..859746 - 237 WP_000368687.1 hypothetical protein -
MUA50_RS04140 (859971) 859971..860552 + 582 WP_001140696.1 histidine phosphatase family protein -
MUA50_RS04145 (860625) 860625..861242 - 618 WP_000255548.1 LysE/ArgO family amino acid transporter -
MUA50_RS04150 (861398) 861398..861892 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
MUA50_RS04155 (862291) 862291..862713 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
MUA50_RS04160 (862861) 862861..863577 + 717 WP_000150025.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 853089..893355 40266


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(8-48)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T240290 WP_000052076.1 NZ_CP094772:c858680-858492 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T240290 NZ_LS992188:c36126-35968 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT240290 WP_001059690.1 NZ_CP094772:c858969-858709 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT240290 NZ_LS992188:c36394-36170 [Escherichia coli]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References