Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2127986..2128515 Replicon chromosome
Accession NZ_CP094770
Organism Staphylococcus aureus strain IVB6201

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MUA35_RS10665 Protein ID WP_000621175.1
Coordinates 2127986..2128348 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag MUA35_RS10670 Protein ID WP_000948331.1
Coordinates 2128345..2128515 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA35_RS10645 (MUA35_10610) 2124964..2125734 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
MUA35_RS10650 (MUA35_10615) 2125709..2126188 - 480 WP_001190825.1 anti-sigma B factor RsbW -
MUA35_RS10655 (MUA35_10620) 2126190..2126516 - 327 WP_001052491.1 anti-sigma factor antagonist -
MUA35_RS10660 (MUA35_10625) 2126635..2127636 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
MUA35_RS10665 (MUA35_10630) 2127986..2128348 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA35_RS10670 (MUA35_10635) 2128345..2128515 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA35_RS10675 (MUA35_10640) 2128600..2129748 - 1149 WP_001281143.1 alanine racemase -
MUA35_RS10680 (MUA35_10645) 2129814..2130173 - 360 WP_000581197.1 holo-ACP synthase -
MUA35_RS10685 (MUA35_10650) 2130177..2130668 - 492 WP_262538389.1 PH domain-containing protein -
MUA35_RS10690 (MUA35_10655) 2130661..2132238 - 1578 WP_262607635.1 PH domain-containing protein -
MUA35_RS10695 (MUA35_10660) 2132231..2132710 - 480 WP_001287083.1 hypothetical protein -
MUA35_RS10700 (MUA35_10665) 2132919..2133479 - 561 WP_025788990.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T240282 WP_000621175.1 NZ_CP094770:c2128348-2127986 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T240282 NZ_LS992185:c4740376-4740269 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT240282 WP_000948331.1 NZ_CP094770:c2128515-2128345 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT240282 NZ_LS992185:4740424-4740490 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References