Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TscAT/- |
| Location | 2076357..2076886 | Replicon | chromosome |
| Accession | NZ_CP094770 | ||
| Organism | Staphylococcus aureus strain IVB6201 | ||
Toxin (Protein)
| Gene name | TscT | Uniprot ID | K7ZRX2 |
| Locus tag | MUA35_RS10395 | Protein ID | WP_001103933.1 |
| Coordinates | 2076357..2076674 (-) | Length | 106 a.a. |
Antitoxin (Protein)
| Gene name | TscA | Uniprot ID | A0A2X2M557 |
| Locus tag | MUA35_RS10400 | Protein ID | WP_001058488.1 |
| Coordinates | 2076677..2076886 (-) | Length | 70 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUA35_RS10370 (MUA35_10335) | 2071628..2071969 | - | 342 | WP_001161492.1 | hypothetical protein | - |
| MUA35_RS10375 (MUA35_10340) | 2072359..2073000 | - | 642 | WP_262537536.1 | pathogenicity island protein | - |
| MUA35_RS10380 (MUA35_10345) | 2072997..2073377 | - | 381 | WP_000356927.1 | hypothetical protein | - |
| MUA35_RS10385 (MUA35_10350) | 2073707..2075407 | - | 1701 | WP_262607625.1 | DUF927 domain-containing protein | - |
| MUA35_RS10390 (MUA35_10355) | 2075421..2076290 | - | 870 | WP_262538431.1 | primase alpha helix C-terminal domain-containing protein | - |
| MUA35_RS10395 (MUA35_10360) | 2076357..2076674 | - | 318 | WP_001103933.1 | DUF1474 family protein | Toxin |
| MUA35_RS10400 (MUA35_10365) | 2076677..2076886 | - | 210 | WP_001058488.1 | hypothetical protein | Antitoxin |
| MUA35_RS10405 (MUA35_10370) | 2076879..2077025 | - | 147 | WP_076742779.1 | pathogenicity island protein | - |
| MUA35_RS10410 (MUA35_10375) | 2077022..2077339 | - | 318 | WP_000481967.1 | helix-turn-helix domain-containing protein | - |
| MUA35_RS10415 (MUA35_10380) | 2077344..2077562 | - | 219 | WP_000153640.1 | helix-turn-helix transcriptional regulator | - |
| MUA35_RS10420 (MUA35_10385) | 2077735..2078409 | + | 675 | WP_262538429.1 | helix-turn-helix transcriptional regulator | - |
| MUA35_RS10425 (MUA35_10390) | 2078423..2079595 | + | 1173 | WP_262607626.1 | site-specific integrase | - |
| MUA35_RS10430 (MUA35_10395) | 2079665..2081281 | - | 1617 | WP_000240642.1 | chaperonin GroEL | - |
| MUA35_RS10435 (MUA35_10400) | 2081356..2081640 | - | 285 | WP_000917289.1 | co-chaperone GroES | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | groEL | 2062385..2084647 | 22262 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12511.13 Da Isoelectric Point: 4.6364
>T240281 WP_001103933.1 NZ_CP094770:c2076674-2076357 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE
Download Length: 318 bp
>T240281 NZ_LS992185:4321656-4322120 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAACCCCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAACCCCATTGA
Antitoxin
Download Length: 70 a.a. Molecular weight: 8287.31 Da Isoelectric Point: 4.2820
>AT240281 WP_001058488.1 NZ_CP094770:c2076886-2076677 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE
Download Length: 210 bp
>AT240281 NZ_LS992185:4321321-4321656 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | K7ZRX2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2X2M557 |