Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1910029..1910805 Replicon chromosome
Accession NZ_CP094770
Organism Staphylococcus aureus strain IVB6201

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag MUA35_RS09315 Protein ID WP_197805632.1
Coordinates 1910029..1910181 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag MUA35_RS09320 Protein ID WP_262607583.1
Coordinates 1910206..1910805 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA35_RS09295 (MUA35_09265) 1905076..1906188 - 1113 WP_000437967.1 GAF domain-containing sensor histidine kinase -
MUA35_RS09300 (MUA35_09270) 1906351..1907172 + 822 WP_000669377.1 RluA family pseudouridine synthase -
MUA35_RS09305 (MUA35_09275) 1907622..1909007 - 1386 WP_262607582.1 class II fumarate hydratase -
MUA35_RS09310 (MUA35_09280) 1909203..1909598 - 396 WP_000901023.1 hypothetical protein -
MUA35_RS09315 (MUA35_09285) 1910029..1910181 - 153 WP_197805632.1 SAS053 family protein Toxin
MUA35_RS09320 (MUA35_09290) 1910206..1910805 - 600 WP_262607583.1 glucosamine-6-phosphate isomerase Antitoxin
MUA35_RS09325 (MUA35_09295) 1910964..1911434 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MUA35_RS09330 (MUA35_09300) 1911439..1912566 - 1128 WP_262607584.1 tRNA epoxyqueuosine(34) reductase QueG -
MUA35_RS09335 (MUA35_09305) 1912717..1913439 - 723 WP_192860286.1 amino acid ABC transporter ATP-binding protein -
MUA35_RS09340 (MUA35_09310) 1913432..1914889 - 1458 WP_262607585.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5922.25 Da        Isoelectric Point: 3.8849

>T240280 WP_197805632.1 NZ_CP094770:c1910181-1910029 [Staphylococcus aureus]
MSKDKDPKLNYHDEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T240280 NZ_CP094770:c1910181-1910029 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGATGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22385.55 Da        Isoelectric Point: 5.1445

>AT240280 WP_262607583.1 NZ_CP094770:c1910805-1910206 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYVADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT240280 NZ_CP094770:c1910805-1910206 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGTTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACTGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATATTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCTGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References