Detailed information of TA system TA240280

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1910029..1910805
• Replicon: chromosome
• Accession: NZ_CP094770
• Organism: Staphylococcus aureus strain IVB6201

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: MUA35_RS09315
• Protein ID: WP_197805632.1
• Coordinates: 1910029..1910181 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: MUA35_RS09320
• Protein ID: WP_262607583.1
• Coordinates: 1910206..1910805 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA35_RS09295 (MUA35_09265)	1905076..1906188	-	1113	WP_000437967.1	GAF domain-containing sensor histidine kinase	-
MUA35_RS09300 (MUA35_09270)	1906351..1907172	+	822	WP_000669377.1	RluA family pseudouridine synthase	-
MUA35_RS09305 (MUA35_09275)	1907622..1909007	-	1386	WP_262607582.1	class II fumarate hydratase	-
MUA35_RS09310 (MUA35_09280)	1909203..1909598	-	396	WP_000901023.1	hypothetical protein	-
MUA35_RS09315 (MUA35_09285)	1910029..1910181	-	153	WP_197805632.1	SAS053 family protein	Toxin
MUA35_RS09320 (MUA35_09290)	1910206..1910805	-	600	WP_262607583.1	glucosamine-6-phosphate isomerase	Antitoxin
MUA35_RS09325 (MUA35_09295)	1910964..1911434	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
MUA35_RS09330 (MUA35_09300)	1911439..1912566	-	1128	WP_262607584.1	tRNA epoxyqueuosine(34) reductase QueG	-
MUA35_RS09335 (MUA35_09305)	1912717..1913439	-	723	WP_192860286.1	amino acid ABC transporter ATP-binding protein	-
MUA35_RS09340 (MUA35_09310)	1913432..1914889	-	1458	WP_262607585.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5922.25 Da
• Isoelectric Point: 3.8849

>T240280 WP_197805632.1 NZ_CP094770:c1910181-1910029 [Staphylococcus aureus]
MSKDKDPKLNYHDEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T240280 NZ_CP094770:c1910181-1910029 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGATGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22385.55 Da
• Isoelectric Point: 5.1445

>AT240280 WP_262607583.1 NZ_CP094770:c1910805-1910206 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYVADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT240280 NZ_CP094770:c1910805-1910206 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGTTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACTGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATATTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCTGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA