Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 852150..852627 | Replicon | chromosome |
| Accession | NZ_CP094770 | ||
| Organism | Staphylococcus aureus strain IVB6201 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | T1Y7S2 |
| Locus tag | MUA35_RS04095 | Protein ID | WP_000052076.1 |
| Coordinates | 852150..852338 (-) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | T1Y6P8 |
| Locus tag | MUA35_RS04100 | Protein ID | WP_001059690.1 |
| Coordinates | 852367..852627 (-) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUA35_RS04065 (MUA35_04045) | 848141..848662 | + | 522 | WP_262537147.1 | hypothetical protein | - |
| MUA35_RS04070 (MUA35_04050) | 849003..849689 | + | 687 | WP_001641381.1 | thermonuclease family protein | - |
| MUA35_RS04075 (MUA35_04055) | 850046..850246 | + | 201 | WP_001059082.1 | cold-shock protein | - |
| MUA35_RS04080 (MUA35_04060) | 850741..850959 | - | 219 | WP_000005880.1 | hypothetical protein | - |
| MUA35_RS04085 (MUA35_04065) | 851021..851305 | - | 285 | WP_262607946.1 | hypothetical protein | - |
| MUA35_RS04090 (MUA35_04070) | 851393..851962 | - | 570 | WP_001106648.1 | lipoprotein N-acylation protein LnsA | - |
| MUA35_RS04095 (MUA35_04075) | 852150..852338 | - | 189 | WP_000052076.1 | hypothetical protein | Toxin |
| MUA35_RS04100 (MUA35_04080) | 852367..852627 | - | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
| MUA35_RS04105 (MUA35_04085) | 852968..853171 | + | 204 | WP_000145163.1 | sterile alpha motif-like domain-containing protein | - |
| MUA35_RS04110 (MUA35_04090) | 853168..853404 | - | 237 | WP_000368687.1 | hypothetical protein | - |
| MUA35_RS04115 (MUA35_04095) | 853629..854210 | + | 582 | WP_001140691.1 | histidine phosphatase family protein | - |
| MUA35_RS04120 (MUA35_04100) | 854283..854900 | - | 618 | WP_262607947.1 | LysE/ArgO family amino acid transporter | - |
| MUA35_RS04125 (MUA35_04105) | 855056..855550 | - | 495 | WP_000569881.1 | GNAT family N-acetyltransferase | - |
| MUA35_RS04130 (MUA35_04110) | 855949..856371 | - | 423 | WP_262607948.1 | organic hydroperoxide resistance protein | - |
| MUA35_RS04135 (MUA35_04115) | 856519..857235 | + | 717 | WP_262537141.1 | type I 3-dehydroquinate dehydratase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7142.82 Da Isoelectric Point: 9.9971
>T240277 WP_000052076.1 NZ_CP094770:c852338-852150 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T240277 NZ_LS992185:c3877870-3877559 [Escherichia coli]
ATGCACATCATTTCGAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTATACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAGATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA
ATGCACATCATTTCGAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTATACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAGATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT240277 WP_001059690.1 NZ_CP094770:c852627-852367 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT240277 NZ_LS992185:c3877562-3877143 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGTAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCCGAGTTCGACAAAGCCGTTGCAGCAATGCCGGTT
GGCGTGGCGTTACTTCGTACGCTGATTGATCAACATAATCTGACCTACGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGTCAGATTTTGTCTGGGCAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGTGTTA
AGCCGGAATGGTTTCTTTGA
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGTAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCCGAGTTCGACAAAGCCGTTGCAGCAATGCCGGTT
GGCGTGGCGTTACTTCGTACGCTGATTGATCAACATAATCTGACCTACGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGTCAGATTTTGTCTGGGCAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGTGTTA
AGCCGGAATGGTTTCTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VP18 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VN56 |