Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 398974..399485 Replicon chromosome
Accession NZ_CP094770
Organism Staphylococcus aureus strain IVB6201

Toxin (Protein)


Gene name TscT Uniprot ID -
Locus tag MUA35_RS01810 Protein ID WP_001103943.1
Coordinates 399186..399485 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID -
Locus tag MUA35_RS01805 Protein ID WP_001058486.1
Coordinates 398974..399183 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA35_RS01770 (MUA35_01755) 394327..395316 - 990 WP_250425947.1 Abi family protein -
MUA35_RS01775 (MUA35_01760) 395322..396536 - 1215 WP_262607853.1 site-specific integrase -
MUA35_RS01780 (MUA35_01765) 396540..397352 - 813 WP_049948385.1 hypothetical protein -
MUA35_RS01785 (MUA35_01770) 397466..398161 - 696 WP_031903008.1 helix-turn-helix transcriptional regulator -
MUA35_RS01790 (MUA35_01775) 398306..398518 + 213 WP_000608987.1 hypothetical protein -
MUA35_RS01795 (MUA35_01780) 398551..398823 + 273 WP_262607854.1 helix-turn-helix domain-containing protein -
MUA35_RS01800 (MUA35_01785) 398835..398981 + 147 WP_000784875.1 hypothetical protein -
MUA35_RS01805 (MUA35_01790) 398974..399183 + 210 WP_001058486.1 hypothetical protein Antitoxin
MUA35_RS01810 (MUA35_01795) 399186..399485 + 300 WP_001103943.1 DUF1474 family protein Toxin
MUA35_RS01815 (MUA35_01800) 399560..401176 + 1617 WP_103144518.1 phage resistance protein -
MUA35_RS01820 (MUA35_01805) 401352..402155 + 804 WP_196251784.1 bifunctional DNA primase/polymerase -
MUA35_RS01825 (MUA35_01810) 402142..402414 + 273 WP_001149387.1 hypothetical protein -
MUA35_RS01830 (MUA35_01815) 402416..403057 + 642 WP_262607855.1 pathogenicity island protein -
MUA35_RS01835 (MUA35_01820) 403447..403788 + 342 WP_001161492.1 hypothetical protein -
MUA35_RS01840 (MUA35_01825) 403800..404378 + 579 WP_000846290.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - tsst-1 393316..415400 22084


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11795.24 Da        Isoelectric Point: 4.5689

>T240276 WP_001103943.1 NZ_CP094770:399186-399485 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFDELIQKF
HEIEKASSDVSLATESDDA

Download         Length: 300 bp

>T240276 NZ_LS992185:c3060413-3060162 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8252.31 Da        Isoelectric Point: 4.3718

>AT240276 WP_001058486.1 NZ_CP094770:398974-399183 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT240276 NZ_LS992185:c3060165-3059911 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCTCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCTACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References