Detailed information of TA system TA240275

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1952808..1953285
• Replicon: chromosome
• Accession: NZ_CP094768
• Organism: Staphylococcus aureus strain IVB6202

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: -
• Locus tag: MUA94_RS09765
• Protein ID: WP_262537143.1
• Coordinates: 1953097..1953285 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: MUA94_RS09760
• Protein ID: WP_001059690.1
• Coordinates: 1952808..1953068 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA94_RS09725 (MUA94_09705)	1948200..1948916	-	717	WP_262537141.1	type I 3-dehydroquinate dehydratase	-
MUA94_RS09730 (MUA94_09710)	1949064..1949486	+	423	WP_020977095.1	organic hydroperoxide resistance protein	-
MUA94_RS09735 (MUA94_09715)	1949885..1950379	+	495	WP_000569881.1	GNAT family N-acetyltransferase	-
MUA94_RS09740 (MUA94_09720)	1950535..1951152	+	618	WP_000255553.1	LysE/ArgO family amino acid transporter	-
MUA94_RS09745 (MUA94_09725)	1951225..1951806	-	582	WP_001140691.1	histidine phosphatase family protein	-
MUA94_RS09750 (MUA94_09730)	1952031..1952267	+	237	WP_000368687.1	hypothetical protein	-
MUA94_RS09755 (MUA94_09735)	1952264..1952467	-	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
MUA94_RS09760 (MUA94_09740)	1952808..1953068	+	261	WP_001059690.1	hypothetical protein	Antitoxin
MUA94_RS09765 (MUA94_09745)	1953097..1953285	+	189	WP_262537143.1	hypothetical protein	Toxin
MUA94_RS09770 (MUA94_09750)	1953473..1954042	+	570	WP_001106648.1	lipoprotein N-acylation protein LnsA	-
MUA94_RS09775 (MUA94_09755)	1954130..1954414	+	285	WP_262537144.1	hypothetical protein	-
MUA94_RS09780 (MUA94_09760)	1954476..1954694	+	219	WP_000005880.1	hypothetical protein	-
MUA94_RS09785 (MUA94_09765)	1955190..1955390	-	201	WP_001059082.1	cold-shock protein	-
MUA94_RS09790 (MUA94_09770)	1955747..1956433	-	687	WP_001641381.1	thermonuclease family protein	-
MUA94_RS09795 (MUA94_09775)	1956774..1957295	-	522	WP_262537147.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.77 Da
• Isoelectric Point: 9.6276

>T240275 WP_262537143.1 NZ_CP094768:1953097-1953285 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMQKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T240275 NZ_LS992185:c3060165-3059911 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCTCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCTACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT240275 WP_001059690.1 NZ_CP094768:1952808-1953068 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT240275 NZ_LS992185:c3060413-3060162 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VN56