Detailed information of TA system TA240271

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 770638..771167
• Replicon: chromosome
• Accession: NZ_CP094768
• Organism: Staphylococcus aureus strain IVB6202

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: MUA94_RS03780
• Protein ID: WP_262537544.1
• Coordinates: 770850..771167 (+)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: A0A2X2M557
• Locus tag: MUA94_RS03775
• Protein ID: WP_001058488.1
• Coordinates: 770638..770847 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA94_RS03740 (MUA94_03735)	765885..766169	+	285	WP_000917289.1	co-chaperone GroES	-
MUA94_RS03745 (MUA94_03740)	766244..767860	+	1617	WP_000240642.1	chaperonin GroEL	-
MUA94_RS03750 (MUA94_03745)	767929..769101	-	1173	WP_160325520.1	tyrosine-type recombinase/integrase	-
MUA94_RS03755 (MUA94_03750)	769115..769789	-	675	WP_262538429.1	helix-turn-helix transcriptional regulator	-
MUA94_RS03760 (MUA94_03755)	769962..770180	+	219	WP_000153640.1	helix-turn-helix transcriptional regulator	-
MUA94_RS03765 (MUA94_03760)	770185..770502	+	318	WP_000481967.1	helix-turn-helix domain-containing protein	-
MUA94_RS03770 (MUA94_03765)	770499..770645	+	147	WP_076742779.1	pathogenicity island protein	-
MUA94_RS03775 (MUA94_03770)	770638..770847	+	210	WP_001058488.1	hypothetical protein	Antitoxin
MUA94_RS03780 (MUA94_03775)	770850..771167	+	318	WP_262537544.1	DUF1474 family protein	Toxin
MUA94_RS03785 (MUA94_03780)	771234..772103	+	870	WP_262538431.1	primase alpha helix C-terminal domain-containing protein	-
MUA94_RS03790 (MUA94_03785)	772117..773817	+	1701	WP_262538433.1	DUF927 domain-containing protein	-
MUA94_RS03795 (MUA94_03790)	774147..774527	+	381	WP_000356927.1	hypothetical protein	-
MUA94_RS03800 (MUA94_03795)	774524..775165	+	642	WP_262537536.1	pathogenicity island protein	-
MUA94_RS03805 (MUA94_03800)	775555..775896	+	342	WP_001161492.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL	765885..793874	27989

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12525.16 Da
• Isoelectric Point: 4.7515

>T240271 WP_262537544.1 NZ_CP094768:770850-771167 [Staphylococcus aureus]
MNWEIKDVMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE

Nucleotide

• Length: 318 bp

>T240271 NZ_LS992185:2476128-2476304 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATAGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8287.31 Da
• Isoelectric Point: 4.2820

>AT240271 WP_001058488.1 NZ_CP094768:770638-770847 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT240271 NZ_LS992185:2476350-2476766 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A2X2M557