Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 718981..719510 Replicon chromosome
Accession NZ_CP094768
Organism Staphylococcus aureus strain IVB6202

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MUA94_RS03510 Protein ID WP_000621175.1
Coordinates 719148..719510 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag MUA94_RS03505 Protein ID WP_000948331.1
Coordinates 718981..719151 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA94_RS03475 (MUA94_03470) 714017..714577 + 561 WP_025788990.1 K(+)-transporting ATPase subunit C -
MUA94_RS03480 (MUA94_03475) 714786..715265 + 480 WP_001287083.1 hypothetical protein -
MUA94_RS03485 (MUA94_03480) 715258..716835 + 1578 WP_262538386.1 PH domain-containing protein -
MUA94_RS03490 (MUA94_03485) 716828..717319 + 492 WP_262538389.1 PH domain-containing protein -
MUA94_RS03495 (MUA94_03490) 717323..717682 + 360 WP_000581197.1 holo-ACP synthase -
MUA94_RS03500 (MUA94_03495) 717748..718896 + 1149 WP_262538391.1 alanine racemase -
MUA94_RS03505 (MUA94_03500) 718981..719151 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA94_RS03510 (MUA94_03505) 719148..719510 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA94_RS03515 (MUA94_03510) 719860..720861 + 1002 WP_262538393.1 PP2C family protein-serine/threonine phosphatase -
MUA94_RS03520 (MUA94_03515) 720980..721306 + 327 WP_001052491.1 anti-sigma factor antagonist -
MUA94_RS03525 (MUA94_03520) 721308..721787 + 480 WP_001190825.1 anti-sigma B factor RsbW -
MUA94_RS03530 (MUA94_03525) 721762..722532 + 771 WP_001041107.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T240270 WP_000621175.1 NZ_CP094768:719148-719510 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T240270 NZ_LS992185:c2209324-2209217 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT240270 WP_000948331.1 NZ_CP094768:718981-719151 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT240270 NZ_LS992185:2209371-2209437 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References