Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 756120..756808 Replicon chromosome
Accession NC_012943
Organism Mycobacterium tuberculosis KZN 1435

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag TBMG_RS03465 Protein ID WP_003403386.1
Coordinates 756120..756557 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O06777
Locus tag TBMG_RS03470 Protein ID WP_003911263.1
Coordinates 756554..756808 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBMG_RS03435 752371..753381 + 1011 WP_009938249.1 ABC transporter ATP-binding protein -
TBMG_RS03440 753769..754152 - 384 WP_003403365.1 ribonuclease VapC6 -
TBMG_RS03445 754247..754402 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
TBMG_RS03450 754478..755194 - 717 WP_009938832.1 CPBP family intramembrane metalloprotease -
TBMG_RS03455 755470..755778 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
TBMG_RS03460 755765..756010 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
TBMG_RS03465 756120..756557 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
TBMG_RS03470 756554..756808 - 255 WP_003911263.1 antitoxin VapB7 Antitoxin
TBMG_RS03475 756922..759285 + 2364 WP_003898547.1 arylsulfatase AtsD -
TBMG_RS03480 759348..759674 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
TBMG_RS03485 759586..759924 + 339 WP_003403405.1 PIN domain-containing protein -
TBMG_RS03490 759921..760094 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T24027 WP_003403386.1 NC_012943:c756557-756120 [Mycobacterium tuberculosis KZN 1435]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

>T24027 NC_012943:c756557-756120 [Mycobacterium tuberculosis KZN 1435]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9450.99 Da        Isoelectric Point: 11.7073

>AT24027 WP_003911263.1 NC_012943:c756808-756554 [Mycobacterium tuberculosis KZN 1435]
MSMRLAHRLQILLDDECHRRITAVARERGVPVATVVREAIDRGLVSPAGRRKSAGRRLLDAADMSVPEPRELKQELEALR
ARRG

Download         Length: 255 bp

>AT24027 NC_012943:c756808-756554 [Mycobacterium tuberculosis KZN 1435]
ATGAGCATGCGTCTGGCGCATCGGCTCCAGATCCTGCTCGACGACGAGTGCCACCGCCGCATCACCGCGGTGGCGCGCGA
GCGAGGCGTCCCGGTCGCAACCGTCGTGCGTGAGGCCATTGATCGAGGCCTCGTCAGCCCCGCCGGTCGCCGCAAGTCCG
CGGGCAGGCGCCTGCTCGACGCCGCCGACATGTCCGTTCCCGAGCCGCGGGAGCTGAAGCAGGAACTCGAGGCCCTCCGG
GCGCGCCGCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB A0A806JQG1

References