240269

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 699252..699766 Replicon chromosome
Accession NZ_CP094768
Organism Staphylococcus aureus strain IVB6202

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag MUA94_RS03420 Protein ID WP_000581792.1
Coordinates 699557..699766 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag MUA94_RS03415 Protein ID WP_000138934.1
Coordinates 699252..699545 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA94_RS03395 (MUA94_03390) 694597..695238 + 642 WP_262538366.1 thiamine phosphate synthase -
MUA94_RS03400 (MUA94_03395) 695324..696196 + 873 WP_000725802.1 membrane protein insertase YidC -
MUA94_RS03405 (MUA94_03400) 696927..697574 - 648 WP_262538368.1 HD domain-containing protein -
MUA94_RS03410 (MUA94_03405) 697602..699086 - 1485 WP_000571549.1 cardiolipin synthase -
MUA94_RS03415 (MUA94_03410) 699252..699545 + 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA94_RS03420 (MUA94_03415) 699557..699766 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
MUA94_RS03425 (MUA94_03420) 699894..700031 + 138 WP_000828354.1 Lmo0850 family protein -
MUA94_RS03430 (MUA94_03425) 700295..701497 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
MUA94_RS03435 (MUA94_03430) 701815..702885 + 1071 WP_256768876.1 D-alanine--D-alanine ligase -
MUA94_RS03440 (MUA94_03435) 702900..704258 + 1359 WP_162635984.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T240269 WP_000581792.1 NZ_CP094768:699557-699766 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T240269 NZ_LS992185:c2208789-2208682 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT240269 WP_000138934.1 NZ_CP094768:699252-699545 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT240269 NZ_LS992185:2208836-2208902 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References